Results 121 to 130 of about 819,498 (286)
This presentation discusses the different perspectives of researchers within the humanities and from a computer scientist and web archivist. The presentation will cover challenges and experiences from each perspective as well as future potentials in ...
Nyvang, Caroline, Zierau, Eld
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
THE ROLE OF PERSISTENT IDENTIFIERS IN E-SCIENCE
Journal of Social Sciences, 2019 The transformations in science produced by the development of ICTs are conceptualized in the model of e-Science. Information on the researchers’ activities in digital form is collected in several systems outside the affiliated institutions. Manuscript submission systems, grant funding applications, data centers, citation indexes, other institutional or
openaire +3 more sources
Persistent identifier distributed system for digital libraries
, 2010 In this paper we present an Italian initiative, involving relevant research institutions and national libraries, aimed at implementing an NBN Persistent Identifiers (PI) infrastructure based on a novel hardware/software architecture.
Brunella Sebastiani +7 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Recording of a presentation that discusses the different perspectives of researchers within the humanities and from a computer scientist and web archivist.
Nyvang, Caroline, Zierau, Eld
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Persistent Identifier ecosystem expands – to instruments!
, 2020 A PID or persistent identifier has been in common use in scientific publishing for around 20 years now. It was introduced as a DOI (Digital Object Identifier), and the digital object in this case was the journal article.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source