Results 251 to 260 of about 46,705 (302)

High-Dose 8 mg Aflibercept for Neovascular Age-Related Macular Degeneration: Who Is Being Treated with This New Agent? [PDF]

Life (Basel)
Liesenhoff C, Meyrl C, Krause D, Eckardt F, Lorger A, Deiters V, Schiefelbein J, Klaas JE, Schworm B, Priglinger SG, Siedlecki J.   +10 more
europepmc   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +8 more
wiley   +1 more source

Research Code Sharing in Support of Gold Standard Science. [PDF]

J Diabetes Sci Technol
Klonoff DC, Espinoza J, Mader JK, Heinemann L, Cobelli C, Kerr D, Kovatchev B, Najafi B, Prahalad P, Zheng Y, Shao MM, Scheideman AF, DuNova AY, Kohn M, Umpierrez GE, Wong TY, Abdel Malek A, Agus MSD, Ahn DT, AlSaad R, Al-Sofiani ME, Armstrong D, Arnold MA, Bee YM, Bequette BW, Bellazzi R, Cengiz E, Chase JG, Chen H, Chen JY, Cichosz SL, Cinar A, Clements MA, Close KL, Cuadros J, Contreras I, Datta G, Dhatariya K, Doyle FJ, Drincic A, Facchinetti A, Fleming GA, Foreman J, Gabbay MAL, Gutierrez-Osuna R, Healey E, Hoang TD, Jacobs PG, Kulzer B, La Belle J, Lee AY, Lee CS, Lee WA, Liepmann D, Maahs D, Mathioudakis N, Meo SA, Metwally AA, Misra S, Mohan V, Moon SJ, Raeder H, Rhee C, Rhee EJ, Scheinker D, Shah VN, Sheng B, Snyder MP, Sode K, Spanakis EK, Svensson J, Vaswani N, Vareth M, Vehi J, Wallia A, Waki K, Wang T, Williams E, Wolf RM, Wong JC, Yeshiwas S, Zilbermint M, Shah SN.   +82 more
europepmc   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Adverse effects of the PENTO(CLO) protocol in the prevention and management of iatrogenic head and neck bone necrosis in cancer patients: A systematic review and meta-analysis. [PDF]

Support Care Cancer
Ribeiro MTL, Pedroso CM, Kadooka MMC, Pérez-de-Oliveira ME, Pires FR, Lopes MA, Santos-Silva AR.   +6 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Very Low-Carbohydrate Breakfast Intervention for Adults with Type 2 Diabetes and Persistent Hyperglycemia: Protocol for a Digital, Nonrandomized Pre-Post Study. [PDF]

JMIR Res Protoc
Hansen A, Raymond K, Simon A, Kim S, Bayandorian H, Marriott D, Saslow LR.   +6 more
europepmc   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Integrated Analysis of Proteomics and Metabolomics Uncovered the Anti-Inflammatory Mechanisms of Baicalin in CIA Rat FLS. [PDF]

Curr Issues Mol Biol
Wang L, Yao S, Wang J, Yang Y, Wang T, Hai M, Zhang W, Wang N, Wan Q.   +8 more
europepmc   +1 more source