Results 161 to 170 of about 596,197 (256)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

How publish-or-perish culture drives evidence fragmentation in oncology. [PDF]

Ann Med
Chau MT, Ofori-Manteaw BB, Ago JL, Bentley-Spuur K, Kerr H, White S.   +5 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Advancing FAIR data towards comparable, organized, predictive AI-ready data for community validation. [PDF]

Commun Biol
Wood-Charlson EM, Åkerström WN, Anderson L, Borton MA, Burley SK, Byers N, Chandramouliswaran I, Costes SV, Dehal PS, Doktycz M, Eloe-Fadrosh E, Henry C, Fagnan K, Fiehn O, Halappanavar M, Hurwitz B, Joachimiak MP, Jungbluth S, Koblitz J, Mahmud G, McCue LA, Metz TO, Mouncey N, Mungall CJ, Nelson TM, Skye V, Saravia-Butler AM, Saripalli VR, Tringe SG, Van Den Bossche T, Arkin AP.   +30 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The Powerful Connections of Open Persistent Identifiers (PIDs)

Persistent Identifiers (PIDs) can act as signposts and coordinates, pointing to information sources and showing connections between research and researchers. Individually, each of these identifiers is useful, but their value rises exponentially when they

core  

A generalist institutional data repository offering both open and restricted access to support NIH data sharing compliance. [PDF]

J Med Libr Assoc
Kim S, Jian X, Vana ML.
europepmc   +1 more source

A Policy Checklist for Enabling Persistence of Identifiers

D-Lib Magazine, 2009
Nick Nicholas, Nigel Ward, Kerry Blinco
openaire   +3 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

ClarID: a human-readable and compact identifier specification for biomedical metadata integration. [PDF]

J Biomed Semantics
Rueda M, Gut IG.
europepmc   +1 more source