Results 241 to 250 of about 2,614,626 (301)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

<i>Helicobacter pylori</i>, persistent infection burden and structural brain imaging markers. [PDF]

Brain Commun
Beydoun MA, Beydoun HA, Hu YH, El-Hajj ZW, Georgescu MF, Noren Hooten N, Li Z, Weiss J, Lyall DM, Waldstein SR, Hedges DW, Gale SD, Launer LJ, Evans MK, Zonderman AB.   +14 more
europepmc   +1 more source

How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease. [PDF]

Proc Natl Acad Sci U S A
Yin R, Melton S, Huseby ES, Kardar M, Chakraborty AK.   +4 more
europepmc   +1 more source

Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System. [PDF]

Int J Mol Sci
Sasaki S, Ogawa H, Katoh H, Honda T.
europepmc   +1 more source

Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients. [PDF]

Virol Sin
Li G, Yang D, Liu X, Zhang T, Liu H, Zou J, Xu Z, Chen X, Dai L, Chen H, Lu F.   +10 more
europepmc   +1 more source

TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection. [PDF]

Nat Commun
Stupar M, Tan L, Kerr ED, De Voss CJ, Forde BM, Schulz BL, West NP.   +6 more
europepmc   +1 more source

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host

Guerra-Assunção JA, McErlean R, Townsend K, Flaxl LM, Tian SJ, Swadling L, Breuer J, Lowe DM.   +7 more
europepmc   +1 more source

From Acute to Persistent Infection: Revealing Phylogenomic Variations in Salmonella Agona

Waters EV, Lee WWY, Ismail Ahmed A, Chattaway M, Langridge GC.   +4 more
europepmc   +1 more source

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Determinants of persistent Salmonella infections

Current Opinion in Immunology, 2023
Persistent bacterial infections constitute an enormous challenge for public health. Amongst infections with other bacteria, infections with typhoidal and nontyphoidal Salmonella enterica serovars can result in long-term infections of the human and animal host. Persistent infections that are asymptomatic are difficult to identify and thus can serve as a
Katrin, Ehrhardt, Anna-Lena, Becker, Guntram A, Grassl   +2 more
openaire   +2 more sources

Persistent bacterial infections and persister cells

Nature Reviews Microbiology, 2017
Many bacteria can infect and persist inside their hosts for long periods of time. This can be due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective killing by antibiotics. Bacteria can survive antibiotic treatment if they are resistant or tolerant to a drug.
Fisher, RA, Gollan, B, Helaine, S
openaire   +3 more sources