Results 71 to 80 of about 3,002 (197)

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Pathogenesis of Adenomyosis: An Integrated Review of Cellular Origins, Molecular Mechanisms, and Intersecting Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework initiated by tissue injury and repair (TIAR), aberrant stem cell activation, or de novo metaplasia ...
Jiang Yang, Xiaochong Li, Yu Peng, Zhongfeng Sun, Lingli Zhang, Jie Duan, Nanbert Zhong   +6 more
wiley   +1 more source

Histopathological spectrum of disorders of sexual development: a case series of seven cases [PDF]

, 2020
Disorders of sexual development (DSD) refer to cases in which there is a discordance among at least two of the following; genetic sex, gonadal sex, genital tract sex and phenotypic sex.
Agale, Shubhangi V., Bolde, Saroj Ashok, Pirosha, Arva Ali, Ramraje, Sushma N.   +3 more
core   +2 more sources

Recurrent Constellations of Embryonic Malformations (RCEM): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With RCEM and Suggest a Reactive Oxygen Species Pathogenesis

Birth Defects Research, Volume 118, Issue 3, March 2026.
ABSTRACT Background No consistent genetic etiology has been found for a group of six different conditions in humans with multiple malformations called “recurrent constellations of embryonic malformations” (RCEM). Recent studies indicate hypoxia/reoxygenation and generation Reactive Oxygen Species (ROS) as an underlying mechanism for RCEM with the ...
Aaron P. Adam, Helen E. Ritchie, Margaret P. Adam, Bengt R. Danielsson   +3 more
wiley   +1 more source

Laparoscopic orchidopexy in persistent Mullerian duct syndrome [PDF]

, 2018
Purpose When faced with the diagnosis of PMDS, the question still remains as to  what is the best approach to Müllerian structures. The aim of this study was to  describe a novel operative approach considering the vascular anatomy and malignant potential
Ahmed, Kabeer, Jacob, Tarun J., Jehangir, Susan, Ninan, Pradeep J., Thomas, Reju J.   +4 more
core   +2 more sources

AMHR2 mutation in persistent Müllerian duct syndrome: A case of transverse testicular ectopia

UroPrecision, Volume 4, Issue 1, Page 64-68, March 2026.
Abstract Backgroud Persistent Müllerian duct syndrome (PMDS) is a rare condition characterized by the persistence of Müllerian duct structures in genotypic and phenotypic males. Case Presentation We present the case of a 4‐month‐old male with PMDS who presented with transverse testicular ectopia. The patient underwent diagnostic laparoscopic orchiopexy
Hangcheng Fu, Weijing Huang, Jeffrey T. White   +2 more
wiley   +1 more source

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort [PDF]

, 2016
BACKGROUND: Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often difficult and currently only 13% of patients receive an accurate clinical genetic ...
Bergman, P., Bouty, A., Brown, J., Cameron, F., Eggers, S., et al., Grover, S., Heloury, Y., Hewitt, J., Hutson, J., Kimber, C., Knarston, I., Lambeth, L., O'Connell, M., Ohnesorg, T., Robevska, G., Sadedin, S., Tan, T., van den Bergen, J., Werther, G., Zacharin, M.   +20 more
core   +1 more source

Classification conundrum: Persistent mullerian duct syndrome with hypospadias

Archives of Medicine and Health Sciences, 2016
The disorders of sex development (DSD) are uncommon and have wide phenotypic variation. Due to this, they often cannot be classified properly and go unreported.
Sheetal Arora, Ashish Kumar Mandal
doaj   +1 more source

The Impact of Serum Oestradiol and Progesterone Levels on Intraocular Pressure and Systemic Health: Hormonal and Physiological Interactions in Female Dogs

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
• Serum oestradiol and progesterone levels were evaluated in relation to intraocular pressure in female dogs. • Systemic physiological parameters, particularly body weight and systolic blood pressure, showed positive associations with intraocular pressure. • Progesterone levels were negatively correlated with blood pressure.
Candemir Özcan, Tarik Safak, Ali Risvanli   +2 more
wiley   +1 more source

Clinical Characteristics and Management of Two Cases of Complete Androgen Insensitivity Syndrome With Germ Cell Tumors

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Androgen insensitivity syndrome (AIS) is an X‐linked recessive genetic disorder caused by mutations in the androgen receptor (AR) gene, leading to androgen resistance and disorders of sex development (DSD) in 46, XY individuals. It is classified into three phenotypes: complete (CAIS), partial (PAIS), and mild (MAIS).
Fangming Wang, Dong Wang, Jianxing Li, Nianzeng Xing   +3 more
wiley   +1 more source