Results 41 to 50 of about 2,464,313 (253)

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Persistent symptoms after elective sigmoid resection for diverticulitis

, 2008
PURPOSE: Despite technically successful surgery for diverticular disease, a significant group of patients who experience persistent or recurrent symptoms remains.
Candinas, Daniel, Peter, Matthias K, Egger, Bernhard   +2 more
core   +1 more source

Patients’ perspectives on healthcare factors and symptom course in persistent somatic symptoms: findings from a cross-sectional survey in four European countries

BMJ Public Health
Introduction Persistent somatic symptoms (PSS) are prevalent across Europe. As little is known about affected patients’ healthcare experience and its relationship with symptom outcomes, these were explored in a cross-sectional survey across four European
Bernd Löwe, Fiammetta Cosci, Angelika Weigel, Judith G M Rosmalen, Aleksandra Kustra-Mulder, Martin Liebau, Georg Grewer, Joanna Rymaszewska   +7 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Quality indicators for collaborative care networks in persistent somatic symptoms and functional disorders: a modified delphi study

BMC Health Services Research
Background Care for persistent somatic symptoms and functional disorders (PSS/FD) is often fragmented. Collaborative care networks (CCNs) may improve care quality for PSS/FD.
Nick Mamo, Lineke M. Tak, Manouk A. W. van de Klundert, Tim C. Olde Hartman, Judith G. M. Rosmalen, Denise J. C. Hanssen   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Physical impairments in individuals with Long COVID

Frontiers in Sports and Active Living
ObjectiveThe primary objective was to compare the physical capacities of individuals with Long COVID [Long COVID group (LCG)] to those who had COVID-19 but did not develop persistent symptoms [short COVID group (SCG)], and to individuals without a ...
Imane Salmam, Imane Salmam, Kadija Perreault, Kadija Perreault, Krista L. Best, Krista L. Best, Imane Zahouani, Gilles Drouin, Jean Tittley, François Desmeules, François Desmeules, Alexandre Campeau-Lecours, Alexandre Campeau-Lecours, Simon Beaulieu-Bonneau, Simon Beaulieu-Bonneau, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Simon Deslauriers, Sarah-Maude Brouillard, Katherine Lepage, Jean-Sébastien Roy, Jean-Sébastien Roy   +22 more
doaj   +1 more source