Results 91 to 100 of about 2,357,083 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Zagłada Żydów, 2013 When Jürgen Stroop, the suppressor of the Warsaw Ghetto uprising, was brought in 1947 to Poland, his trial was projected to be the most important of those held to date against prominent Nazi officials in Poland.
Katarzyna Person
doaj +1 more source
Person-centred therapy : myths and reality
, 2004 Debunks seven key myths about person-centred ...
Cooper, Mick
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of Eating DisordersWritten by a researcher with lived experience of long-standing bulimia nervosa, this Matters Arising piece commends Robinson et al. (2024)’s study for its focus on exploring the subjective experiences of patients who are often overlooked in clinical and ...
James Downs
doaj +1 more source
, 2014 First Person Kodachrome is a personal essay film about family photos, memory and ...
Taylor, A
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
BMC Primary CareBackground Primary care professionals play a crucial role in promoting public health, yet they often face challenging work environments characterised by stress of conscience, described as distress felt when external constraints or conflicting ...
Cornelia van Diepen +4 more
doaj +1 more source
William L. Person Oral History
, 1976 The original manuscript transcript of this interview is available in University Archives Oral History Collection in the Special Collections Research Center, Swem Library, College of William and Mary.This interview was conducted as part of the College of ...
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source