Results 91 to 100 of about 101,127 (316)

Dilemas genéticos y la Iglesia Católica

Revista Iberoamericana de Bioética, 2017
En las sociedades occidentales, en las que conviven múltiples paradigmas éticos, los dilemas que plantea la genética son entendidos y resueltos de distintas maneras, según el modo de concebir quién es el ser humano y cuáles son los derechos que avalan su
Juan María Velasco, SJ
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

La persona projectual

, 2023
La tesis comienza con un intento de dividir el mundo del arte en una serie de ámbitos a los que se llega analizando el significado que para cada uno de ellos tiene la palabra proporción. La segunda parte que constituye el objetivo de la tesis es demostrar que, en el periodo románico y principios del gótico catalán, se utilizó un sistema de proporciones
openaire   +4 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Therapist rotation: a novel approach for implementation of trauma-focused treatment in post-traumatic stress disorder

European Journal of Psychotraumatology, 2018
Background: Trauma-focused treatments (TFTs) for patients with post-traumatic stress disorder (PTSD) are highly effective, yet underused by therapists.Objective: To describe a new way of implementing (adequate use of) TFTs, using a therapist rotation ...
Agnes Van Minnen, Lotte Hendriks, Rianne De Kleine, Gert-Jan Hendriks, Marije Verhagen, Ad De Jongh   +5 more
doaj   +1 more source

Personalidad y la conducción de la vida cotidiana

Revista Digital Internacional de Psicología y Ciencia Social, 2017
El propósito principal de este escrito es presentar una teoría sobre las personas que está arraigada en la manera en la que las personas conducen sus vidas cotidianas.
Juan José Yoseff Bernal
doaj   +1 more source

PERSONA Y MÁSCARA

Praxis Filosófica, 2011
El artículo defiende la pertinencia y el valor del término “persona” por la riqueza significativa adquirida a través de la historia de la Filosofía, que le permite, como a ningún otro concepto, definir el ser del hombre. Cuatro momentos de la historia se pueden destacar por la manera en que recrean su sentido: en la filosofía griega “persona”  está ligado 
Betancur García, Marta Cecilia
openaire   +4 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source