Results 71 to 80 of about 214,122 (263)
Ser humano y persona humana análisis crítico del concepto de persona de Peter Singer
El concepto de persona, de centralidad inapelable en la historia de la filosofía occidental, se encuentra directamente implicado en las cuestiones más relevantes del ámbito ético y bioético y es una pieza clave en la fundamentación misma de la moral.
Berríos Garaycochea, Miriam
core +1 more source
Using Systemability Function for Periodic Replacement Policy in Real Environments
, 2014 In the last decades, various maintenance policies have been developed and widely used, including, but not limited to replacement policy and preventive maintenance policy, depending on an accurate estimation of the reliability and the failure intensity ...
Fabio Sgarbossa +4 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Persona y educación en Mounier [PDF]
, 2019 Mounier es educador; todo su pensamiento tiende al encuentro personal de cada hombre en sí mismo; ser persona y serlo auténticamente, es el fin de la educación personalista; «la personalización es el bien supremo del Universo».
Capitán Díaz, Alfonso
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2018 Persona Non Grata Sonata is a digital video essay (6’32”). Using sequences from Persona (Ingmar Bergman, 1966) and Autumn Sonata (Ingmar Bergman, 1978), it was made by Catherine Grant and Amber Jacobs in 2018.
Grant, Catherine, Jacobs, Amber
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2021 Il contributo propone alcune linee concettuali per un ripensamento del riferimento personalista che voglia essere incisivo e non meramente esigenziale. In Più precisamente si individuano tre possibili direzioni: tradizione, metodo e aree di operatività.
Giovanni Bombelli
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