Results 181 to 190 of about 104,754 (312)

A Generative Expert-Narrated Simplification Model for Enhancing Health Literacy Among the Older Population. [PDF]

Bioengineering (Basel)
Abdusalomov A, Umirzakova S, Mirzakhalilov S, Kutlimuratov A, Nasimov R, Temirov Z, Jeong W, Choi H, Whangbo TK.   +8 more
europepmc   +1 more source

La autonomía en las personas con diversidad funcional y el rol de la familia en el proceso de autodeterminación e independencia

Cecilia Isabel Merino Armijos, Sandra Jackeline Urgilés-León, Nancy Yolanda Fernández-Aucapiña   +2 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Optimizing large language models for detecting symptoms of depression/anxiety in chronic diseases patient communications. [PDF]

NPJ Digit Med
Kim J, Ma SP, Chen ML, Galatzer-Levy IR, Torous J, van Roessel PJ, Sharp C, Pfeffer MA, Rodriguez CI, Linos E, Chen JH.   +10 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Helpful assistant or fruitful facilitator? Investigating how personas affect language model behavior. [PDF]

PLoS One
Luz de Araujo PH, Roth B.
europepmc   +1 more source

Informe Maltrato hacia personas mayores en Cuba en el ámbito doméstico familiar: de la invisibilidad a un problema de interés público

Cuido60
openalex   +1 more source

Cuidadores informales de personas dependientes en chile. Aspectos psicosociales y culturales [PDF]

, 2013
Deiza Yanet Troncoso Miranda
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Personality masks of mothers of young children: measure development and parenting behavior impact. [PDF]

Front Psychol
Li R, Yan S, Fang S, Xu J, Sun C, Shen T.   +5 more
europepmc   +1 more source