Results 61 to 70 of about 101,127 (316)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Efectos del Dólar y Petróleo en el Desempleo Urbano en Ecuador
Revista Economía y Negocios, 2018 La recesión económica ocurrida en Ecuador durante 2016 generó un debate académico acerca del efecto de variables exógenas en el mercado laboral. El presente trabajo analiza el impacto del petróleo y el dólar estadounidense en el desempleo urbano en ...
Guillermo Avellán-Solines
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
, 2018 This chapter asks what room is there for stand-up comedy as social critique in a ‘post-abjection’ society. In a society where a New Left politics is normative, ‘common sense’, where does this leave radical critique for stand-up comedians? If New Left ideals are mainstream ‘political sense’, how do comedians face up to the obligations of New Left ...
openaire +3 more sources
Frontiers in Psychology, 2016 Children with Specific Language Impairment (SLI) often experience emotional and social difficulties. In general, problems in social emotional functioning can be cognitively explained in terms of Theory of Mind (ToM).
Constance Vissers +2 more
doaj +1 more source
From Persona to Techsona [PDF]
, 2013 In this paper we introduce the notion of techsona, as a possible counterpart design instrument to personas. We use a case study to illustrate a design process where techsonas help pinpoint technological ideas and alternatives and analyze these systematically.
Bødker, Susanne +1 more
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Alzheimer's Disease: From Genes to Nutrition
European Journal of Inflammation, 2014 Alzheimer's disease (AD) is widely identified as the most common cause of sporadic dementia. Its aetiology is still debated, as despite several hypotheses, different factors seem to play a role in its establishment and development.
L. Venturini +7 more
doaj +1 more source
Scientific Reports, 2023 Being immersed in a natural context has a beneficial and pervasive impact on well-being. Virtual Reality (VR) is a technology that can help expose people to naturalistic scenarios virtually, overcoming obstacles that prevent them from visiting real ...
Susanna Pardini +14 more
doaj +1 more source