Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
A Blockchain-Based End-to-End Data Protection Model for Personal Health Records Sharing: A Fully Homomorphic Encryption Approach. [PDF]
Sensors (Basel), 2022 Vanin FNDS +6 more
europepmc +1 more source
Advanced Science, EarlyView.Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang +10 more
wiley +1 more source
Functionalities and Issues in the Implementation of Personal Health Records: Systematic Review. [PDF]
J Med Internet Res, 2021 Harahap NC, Handayani PW, Hidayanto AN.
europepmc +1 more source
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Public attitudes toward cloud computing and willingness to share personal health records (PHRs) and genome data for health care research in Japan. [PDF]
Hum Genome Var, 2023 Kusunose M, Muto K.
europepmc +1 more source
Abstract Representation of Movement Parameters in Basal Ganglia Output
Advanced Science, EarlyView.The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero +3 more
wiley +1 more source
Development of a data platform for monitoring personal health records in Japan: The Sustaining Health by Integrating Next-generation Ecosystems (SHINE) Study. [PDF]
PLoS One, 2023 Fukuda H +8 more
europepmc +1 more source
Advanced Science, EarlyView.TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang +8 more
wiley +1 more source
Which are the vital factors of mobile personal health records applications that promote continued usage? A perspective on technology fit and social capital. [PDF]
Digit Health, 2023 Liu YY, Lu HP, Chen CS.
europepmc +1 more source