Results 31 to 40 of about 733,815 (225)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Complete genome of Escherichia coli sequence type 73 with acquired blaTEM-1 and high genotypic virulence load identified in human saliva

Journal of Global Antimicrobial Resistance
Objectives: Escherichia coli sequence type (ST) 73 is a pandemic lineage of the ExPEC (Extraintestinal Pathogenic E. coli) family associated with conserved virulence. We report the complete genome of a genomically hypervirulent E.
Francesca McDonagh, Anna Tumeo, Elaine K. Murray, Brian Hallahan, Georgios Miliotis   +4 more
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Complete genome and comparative genomic analysis of cefpodoxime resistant Pantoea septica strain GABEPS69 isolated from saliva of a patient diagnosed with treatment resistant schizophrenia

International Journal of Medical Microbiology
Objectives: This study aims to generate the first complete genome of Pantoea septica and provide a thorough genomic characterisation of this under-documented species. The study seeks to enhance understanding of P. septica, clarifying features relevant to
Francesca McDonagh, Aneta Kovarova, Anna Tumeo, Andy O’Connor, Niamh McEvoy, Aneesa Mangalam Lonappan, Kasthuri Venkateswaran, Elaine K. Murray, Brian Hallahan, Georgios Miliotis   +9 more
doaj   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Flavonoid-modulated JAK-STAT signaling mitigates malignant transformation and drug resistance in breast tumors: A clinically relevant 3PM-guided innovation

Journal of Advanced Research
Background: Breast cancer (BC) treatment efficacy is often compromised by tumor cell plasticity and multidrug resistance of multi-factorial origin.
Peter Kubatka, Mykhailo Huniadi, Andrea Kapinova, Natalia Nosalova, Elizabeth Varghese, Dana Blahutova, Slavomir Hornak, Alexandra Trbolova, Kamil Biringer, Katarina Adamicova, Dasa Cizkova, Dietrich Büsselberg, Olga Golubnitschaja   +12 more
doaj   +1 more source

Personalised Clinical Decision Support For Diabetes Management Using Real-time Data [PDF]

, 2017
PEPPER (Patient Empowerment through Predictive PERsonalised decision support) is an EU-funded research project to develop a personalised clinical decision support system for Type 1 diabetes self-management. The tool provides insulin bolus dose advice and
Georgiou, Pantelis, Fernández-Real, Jose Manuel, Martin, Clare, Martin, Clare (5288857), Shapley, Julian, Gay, Pablo (5333716), Wos, Marzena (5288860), Innocenti, Bianca (5333695), Aldea, Arantza, Reddy, Monika, Aldea, Arantza (5333698), Harrison, R., Fernández-Real Lemos, José Manuel, Nita, Lucian, Harrison, R. (5333719), Herrero i Viñas, Pau, Reddy, Monika (5333689), Pesl, Peter (5333686), Fernández-Real, Jose Manuel (5333692), Duce, David, Leal, Yenny, Oliver, Nick, Gay, Pablo, Innocenti, Bianca, Waite, Marion (5333701), Oliver, Nicholas, Herrero, Pau, Leal, Yenny (5288866), López Ibáñez, Beatriz, Torrent-Fontbona, Ferran, Brown, Daniel (5333704), Brown, Daniel, López, Beatriz, Nita, Lucian (5333419), Shapley, Julian (5333410), Petite, Roberto, López, Beatriz (5333416), Oliver, Nicholas (5333713), Gay Sacristán, Pablo, Pesl, Peter, Waite, Marion, Wos, Marzena, Georgiou, Pantelis (5333710), Herrero, Pau (5333425), Torrent-Fontbona, Ferran (5333707), Petite, Roberto (5333722), Leal Moncada, Yenny Teresa   +46 more
core   +1 more source

A Comprehensive Review on Additive Manufacturing of Smart Components: Technologies, Applications, and Future Scope

Advanced Intelligent Systems, EarlyView.
How can additive manufacturing enable components that sense, adapt, heal, and power themselves? This review synthesizes recent advances in smart functionalities, manufacturing technologies, and intelligent design strategies, revealing a pathway toward fully integrated, autonomous, and multifunctional systems across diverse engineering sectors. Additive
Aiswarya Rony, P. M. Ushasree, Michael Short, Jinoop Arackal Narayanan   +3 more
wiley   +1 more source

Measuring Child Disadvantage: Comparing Multidimensional and Socioeconomic Approaches for Predicting Developmental Outcomes

Australian Journal of Social Issues, EarlyView.
ABSTRACT Robust measurement of disadvantage is essential to identifying and addressing inequities in children's development. We tested how a multidimensional framework of child disadvantage performed relative to a traditional socioeconomic position (SEP) approach to predict developmental outcomes.
Wei Hong, Fiona Mensah, Elodie O'Connor, Shuaijun Guo, Sharon Goldfeld, Meredith O'Connor, Cindy Pham, Sarah Gray   +7 more
wiley   +1 more source