Results 31 to 40 of about 167,810 (268)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

The Impact of the COVID‐19 Pandemic on the Well‐Being of People With Borderline Personality Disorder: A National Australian Study

Mental Health Science
Social isolation due to the COVID‐19 pandemic was a significantly destabilizing factor for people with borderline personality disorder (BPD). The aim of this study was to investigate the well‐being of Australians diagnosed with BPD during the initial ...
Parvaneh Heidari, Jillian H. Broadbear, Marita Mohammadshahi, Farzaneh Foroughinia, Rita Brown, Sathya Rao   +5 more
doaj   +1 more source

A Temperament-Attachment-Mentalization-Based (TAM) Theory of Personality and Its Disorders

Frontiers in Psychology, 2019
Theories of personality and its disorders need, from time to time, to be revised and updated according to new empirical and conceptual developments. Such development has taken place in the realms of affective neuroscience, evolution, and social cognition.
Sigmund W. Karterud, Mickey T. Kongerslev, Mickey T. Kongerslev   +2 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Transference-focused psychotherapy in an inpatient setting for borderline personality disorders: changes in symptomatology

Research in Psychotherapy
This prospective, naturalistic, longitudinal study examined changes in borderline-specific symptoms in a six-month, manualbased transference-focused psychotherapy (TFP) inpatient treatment for patients with borderline personality disorder (BPD) in ...
Torvi Abel, Moritz Happel, Franca Daerr, Carsten Spitzer, Cord Benecke, Birger Dulz   +5 more
doaj   +1 more source

Change in the Definition of Personality Disorder in Transition to ICD-11: A Look from Clinical and Developmental Perspectives

Psichologija, 2021
The recent body of research reveals fundamental limitations to the categorical concept of a personality disorder that has led researchers to adopt a new personality disorder concept. During the last decade DSM-5 and ICD-11 diagnostic classifications have
Rasa Barkauskienė, Elena Gaudiešiūtė, Gabrielė Skabeikytė   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dysfunctional beliefs and antisocial personality disorder

, 2008
Beck identified dysfunctional beliefs associated with personality disorders and these form the basis of the Personality Belief Questionnaire (PBQ). The PBQ has not yet been empirically examined in relation to antisocial personality disorder (ASPD); here,
Christopher, Gary, McMurran, Mary
core   +1 more source

Supporting parents with borderline personality disorder through a parenting group intervention: a randomized controlled trial

Borderline Personality Disorder and Emotion Dysregulation
Background There is a need for a parenting intervention that specifically addresses the concerns for parents with borderline personality disorder (BPD) due to the challenges that these parents experience and the stigma that surrounds parenting with BPD ...
Brin F. S. Grenyer, Charlotte C. van Schie, Dianna R. Bartsch, Laura Cooke-O’Connor, Dominic Kleinig, Kayla R. Steele, Cathy McLeod Everitt   +6 more
doaj   +1 more source