Results 41 to 50 of about 133,386 (264)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Implementation and outcomes of a brief crisis intervention for adolescents with borderline personality features: a pre-post observational study

BMC Psychiatry
Background Suicide is one of the leading causes of death among young people. Borderline personality features have been identified as a risk factor for suicide-related behaviour among adolescents.
Dianna R. Bartsch, Justine C. Price, Luke Tilley, Sophie C. Dahlenburg, Simon Cousins, Mohammed Usman, Sierra Magann, Cathy McLeod Everitt   +7 more
doaj   +1 more source

Attitude of Treating Psychiatrist Towards Personality Disorder

Journal of Nepal Health Research Council, 2018
Background: Worldwide mental health professionals have negative attitude towards personality disorder. Aim of this study was to assess the attitudes toward personality disorder among Nepalese psychiatrists.
Pratikchya Tulachan, Manisha Chapagain, Saraswati Dhungana, Sagun Ballav Pant, Saroj Prasad Ojha   +4 more
doaj   +1 more source

Sexual physical abuse in personality disorder: Menderes personality disorder research results [PDF]

Klinik Psikiyatri Dergisi, 2019
Objective: This study was conducted with the aim of investigating the relationship between different types of childhood trauma and DSM-IV personality disorders.
Hulya Arslantas, Orkun Erkayiran, Cigdem Dereboy, Mehmet Eskin, Ferhan Dereboy   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Teaching transference focused psychotherapy to South African mental health practitioners

South African Journal of Psychiatry
Background: Personality disorders (PDs) are estimated to occur in 6.8% of South Africans and in 45% to 80% of clinical populations. Mental health practitioners often harbour negative attitudes and lack confidence in working with such patients.
Henk S. Temmingh, Iliana Fanidi, Craig Bracken, Tennyson Lee   +3 more
doaj   +1 more source

Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD

Frontiers in Psychiatry, 2020
Gamma ventral capsulotomy (GVC) is a radiosurgical procedure which aims to create lesions in the ventral part of the anterior limb of the internal capsule (ALIC).
Maria Eugênia Copetti, Antonio C. Lopes, Guaraci Requena, Isaac N. S. Johnson, Isaac N. S. Johnson, Benjamin D. Greenberg, Benjamin D. Greenberg, Georg Noren, Nicole C. R. McLaughlin, Roseli G. Shavitt, Eurípedes C. Miguel, Marcelo C. Batistuzzo, Marcelo Q. Hoexter   +12 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source