Results 31 to 40 of about 50,358 (223)
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Context-Aware Unsupervised Clustering for Person Search [PDF]
arXiv, 2021 The existing person search methods use the annotated labels of person identities to train deep networks in a supervised manner that requires a huge amount of time and effort for human labeling. In this paper, we first introduce a novel framework of person search that is able to train the network in the absence of the person identity labels, and propose
arxiv
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
Less is More: Learning to Refine Dialogue History for Personalized Dialogue Generation [PDF]
arXiv, 2022 Personalized dialogue systems explore the problem of generating responses that are consistent with the user's personality, which has raised much attention in recent years. Existing personalized dialogue systems have tried to extract user profiles from dialogue history to guide personalized response generation. Since the dialogue history is usually long
arxiv
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
The Traits of the Personable [PDF]
arXiv, 2002 Information personalization is fertile ground for application of AI techniques. In this article I relate personalization to the ability to capture partial information in an information-seeking interaction. The specific focus is on personalizing interactions at web sites.
arxiv