Results 101 to 110 of about 399,478 (308)

Moving beyond the genome with computer modeling

, 2018
Once personalized computer simulations can provide the appropriate models and explanations to model biological and mechanical processes, we will be able to move beyond genome-based personalized medicine, enabling better use of the valuable medical ...
Christen, Patrik, Patrik Christen
core   +1 more source

The future for diabetic foot ulcer prevention: A paradigm shift from stratified healthcare towards personalized medicine

, 2020
Prevention of diabetic foot ulcers is important to reduce the burden of diabetic foot disease. However, we found that ulcer prevention is underexposed in research and clinical practice.
Woodburn, James, Sicco A. Bus, Jaap J. Van Netten, James Woodburn, Van Netten, Jaap J, Bus, Sicco A, van Netten, Jaap J., Bus, Sicco A.   +7 more
core   +1 more source

Personalized Medicine in Europe

Clinical and Translational Science, 2017
Personalised medicine is a promising new concept for dealing with challenges of health and health systems. With the launch of the International Consortium of Personalised Medicine, which brings together health research funders and policy making organisations, European countries aim to coordinate research and health policy to advance the implementation ...
Nimmesgern, E, Benediktsson, I, Norstedt, I   +2 more
openaire   +2 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

TACC3 in personalized medicine

Oncoscience, 2015
Cells are constantly exposed to endogenous and exogenous DNA damage events. In order to confront DNA damage and to maintain genomic integrity, cells have evolved a fine-tuned network of cellular pathways, collectively known as the DNA damage response (DDR).
Stephen, Murata, Loredana, Campo, Eun-Kyoung, Breuer   +2 more
openaire   +2 more sources

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

Genomic and Personalized Medicine V1-2

, 2013
Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into ...
Willard, Huntington F., Ginsburg, Geoffrey S.   +1 more
core  

FROM PERSONALIZED TO PRECISION MEDICINE

Рациональная фармакотерапия в кардиологии, 2017
The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care.
K. V. Raskina, E. Y. Martynova, A. V. Perfilyev, D. A. Sychev, G. N. Shuev, I. R. Fatkhutdinov, S. V. Musienko, D. A. Nikogosov, I. O. Zhegulina, L. G. Bavykina, Y. E. Poteshkin   +10 more
doaj   +1 more source

The promises of personalized medicine [PDF]

European Journal of Clinical Pharmacology, 2010
The “Personalized Medicine Coalition” formed in 2005 [1] defines personalized medicine as “the application of genomic and molecular data to better target the delivery of health care, facilitate the discovery and clinical testing of new products, and help determine a person’s predisposition to a particular disease or condition.” Personalized medicine ...
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source