Results 101 to 110 of about 4,097,121 (312)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Words matter: distinguishing "personalized medicine" and "biologically personalized therapeutics".

, 2014
"Personalized medicine" has become a generic term referring to techniques that evaluate either the host or the disease to enhance the likelihood of beneficial patient outcomes from treatment interventions.
Francis, Prudence, Piccart, Martine J., Fallowfield, Lesley J, Chariklia Tziraki (5800493), Piccart-Gebhart, Martine, Martine J Piccart (16198832), Soussan-Gutman, Lior, Tziraki, Chariklia, Emanuel, Linda, Francis, Prudence A., Lesley Fallowfield (4461436), Elisabeth G E de Vries (16198829), Cherny, Nathan NI, Linda Emanuel (10771610), Nathan I Cherny (16198826), Alberto Gabizon (202171), David Sidransky (11085), de Vries, Elisabeth Ge E Liesbeth E., Gabizon, Alberto, Sidransky, David, Cherny, Nathan I., de Vries, Elisabeth G. E., Fallowfield, Lesley, Prudence A Francis (9379193), de Vries, Elisabeth G. E. ; id_orcid, Lior Soussan-Gutman (7421744)   +25 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Personalized medicine in glaucoma management

Российский офтальмологический журнал, 2019
The review addresses the management of primary glaucoma as a socially significant multifactorial disease. The main reasons that impede the timely diagnosis and treatment of patients with glaucoma are indicated: blurring of boundaries, conventionality of ...
A. N. Zhuravleva, O. A. Kiseleva, M. O. Kirillova   +2 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Risk prediction of sepsis-associated acute kidney injury: development, validation of a machine learning model with multicenter data

BMC Medical Informatics and Decision Making
Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in intensive care unit (ICU) patients, with high incidence and mortality.
Renzhi Tan, Yongchen Li, Diman Mai, Jingwen Liu, Yushuang Wei, Chao Wang, Zengnan Mo   +6 more
doaj   +1 more source

Metabolomics: moving towards personalized medicine

Italian Journal of Pediatrics, 2009
In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach.
Reniero Fabiano, Giordano Giuseppe, Carraro Silvia, Baraldi Eugenio, Perilongo Giorgio, Zacchello Franco   +5 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Personalized medicine. Closing the gap between knowledge and clinical practice

, 2016
Personalized medicine encompasses a broad and evolving field informed by a patient distinctive information and biomarker profile. Although terminology is evolving and some semantic interpretations exist (e.g., personalized, individualized, precision), in
Rojas-Villarraga, Adriana, Sarmiento-Monroy, Juan C., Duarte-Rey, Carolina, Bardey, David, Anaya, Juan-Manuel, Castiblanco, John, Marín Montealegre, Valeria, Sarmiento-Monroy, Juan-C   +7 more
core   +1 more source