Results 81 to 90 of about 627,364 (295)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Ensuring sample quality for biomarker discovery studies - Use of ict tools to trace biosample life-cycle [PDF]

, 2015
The growing demand of personalized medicine marked the transition from an empirical medicine to a molecular one, aimed at predicting safer and more effective medical treatment for every patient, while minimizing adverse effects.
Alessandroni, Jhessica, D'Alessandro, Roberta, Della Morte, David, Ferroni, Patrizia, Formica, Vincenzo, Guadagni, Fiorella, Nanni, Umberto, Palmirotta, Raffaele, Riondino, Silvia, Roselli, Mario, Spila, Antonella   +10 more
core  

Personalized medicine gets personal [PDF]

Science-Business eXchange, 2014
Epithelial cancers are the most common malignancies, but immunotherapy development has been stymied because the low mutation frequency of these tumors elicits muted mutation-specific T cell responses. An NCI team has now used next-generation sequencing to identify such rare mutations in one patient and has developed an autologous cell therapy.
openaire   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Dysbiosis of the gut microbiota in calcium oxalate nephrolithiasis is associated with impaired short-chain fatty acid production and systemic metabolomic disruptions

Microbiome
Background The prevalence of calcium oxalate (CaOx) kidney stones is increasing, yet the underlying mechanisms remain incompletely understood. Emerging evidence suggests that gut microbiota—particularly short-chain fatty acid (SCFA)-producing bacteria ...
Xi Chen, Fangxing Zhang, Lang Cheng, Decao Niu, Jianpei Hu, Shengzhu Huang, Fubo Wang, Guijian Pang, Caisheng Huang, Mingli Li, Chao Wang, Zengnan Mo   +11 more
doaj   +1 more source

Computational Biomarker Discovery: From Systems Biology to Predictive and Personalized Medicine Applications [PDF]

, 2010
poster abstractWith the advent of Genome-based Medicine, there is an escalating need for discovering how the modifications of biological molecules, either individually or as an ensemble, can be uniquely associated with human physiological states.
Chen, Jake Y., Huan, Tianxiao, Huang, Hui, Pandey, Ragini, Wu, Xiaogang, Zhang, Fan   +5 more
core  

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer

Journal of Translational Medicine
Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor ...
Hao Yuan, Xingning Mao, Yunkun Yan, Rong Huang, Qingyun Zhang, Yanyu Zeng, Mengying Bao, Yan Dai, Bo Fang, Junhao Mi, Yuli Xie, Xiang Wang, Haiying Zhang, Zengnan Mo, Rirong Yang   +14 more
doaj   +1 more source

Metabolomics: moving towards personalized medicine

Italian Journal of Pediatrics, 2009
In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach.
Reniero Fabiano, Giordano Giuseppe, Carraro Silvia, Baraldi Eugenio, Perilongo Giorgio, Zacchello Franco   +5 more
doaj   +1 more source