Results 71 to 80 of about 361,585 (263)

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Embracing personalized medicine in dentistry

Journal of Pharmacy and Bioallied Sciences, 2019
Aim: The aim of this systematic review was to evaluate the number of articles in the area of personalized medicine specific to dentistry. Materials and Methods: Electronic search using three databases was performed using PubMed, Embase, and Scopus search.
Manchala Sesha Reddy, Shishir Ram Shetty, Venkataramana Vannala   +2 more
doaj   +1 more source

Empowering Adult Learning How AI Fuels Progress Across Disciplines and Professions

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of artificial intelligence (AI) as a transformative cognitive partner across educational and professional fields. It explores how AI shifts attention away from routine technical tasks and toward human‐centered skills such as critical thinking, ethical decision‐making, and professional judgment.
Rachel Wlodarsky
wiley   +1 more source

Effect of plasma aldosterone concentration on serum uric acid metabolism

Guangxi Yike Daxue xuebao
Objective To explore the associations between primary aldosteronism (PA)-related phenotypes and serum uric acid (SUA) levels as well as the risk of hyperuricemia. Methods A total of 1, 986 high-risk individuals for PA were selected from those screened at
WEI Yushuang, LI Mingli, XU Mingjie, YAN Boteng, JIN Xihui, MAI Xiaoyou, WU Yongxian, HUANG Shengzhu, MO Zengnan   +8 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Personalized Medicine and Therapeutics

Personalized medicine is a new medical approach that uses a patient’s genetic profile to guide disease prevention, diagnosis, and treatment. It combines current medicine with molecular breakthroughs to target patients individually, increasing therapeutic efficacy.
Sarhangi, Negar, Patrinos, George P, Aghaei Meybodi, Hamid Reza, Nikfar, Shekoufeh, Sarrami, Behnaz, Kiani, Pantea, Larijani, B., Khodayari, Nazli, Hasanzad, Mandana   +8 more
openaire   +1 more source

Expanding the Phenotypic Spectrum of Anauxetic Dysplasia Type 3: Reporting an Iranian Family With Unique Systemic Features and NEPRO Gene Variant

Clinical Case Reports
The cartilage hair hypoplasia‐anauxetic dysplasia (CHH‐AD) spectrum represents a group of rare autosomal recessive skeletal dysplasias with significant phenotypic heterogeneity.
Mahnaz Mohammadi Kian, Sara Sheikholeslami, Maryam Kiani Feizabadi, Amir Mohammad Roshanaeizadeh, Atousa Haghi, Ahmad Reza Salehi Chaleshtori, Hamid Reza Moazzeni   +6 more
doaj   +1 more source