Results 61 to 70 of about 4,097,121 (312)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Training the Future Leaders in Personalized Medicine

, 2016
The era of personalized medicine has arrived, and with it a need for leaders in this discipline. This generation of trainees requires a cadre of new skill sets to lead the implementation of personalized medicine into mainstream healthcare.
Sweetser, David, Heather Mason-Suares, Neal Lindeman, Lindeman, Neal, Cynthia Morton, Mason-Suares, Heather, David Sweetser, Morton, Cynthia   +7 more
core   +1 more source

Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine

, 2022
Colorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient ...
Takumi Kiwaki, Hiroaki Kataoka, Kataoka, Hiroaki, Kiwaki, Takumi   +3 more
core   +1 more source

The evolution of personalized healthcare and the pivotal role of European regions in its implementation [PDF]

, 2021
Personalized medicine (PM) moves at the same pace of data and technology and calls for important changes in healthcare. New players are participating, providing impulse to PM.
Ballensiefen, W, Turrini, M, Borgono, Elio, Borgonovi, Elio, Neumuth, Thomas, Nardini, Christine, D’Errico, Gianni, Osmani, Venet, Neumuth, T, Borgonovi, E, D’Errico, G, Frosini, Andrea, Cormio, Paola G, Turrini, Mauro, Frosini, A, Cormio, PG, Lionis, C, Ballensiefen, Wolfgang, Lionis, Christos, Nardini, C, Osmani, V, Turrini Mauro, Borgonovi Elio, Neumuth Thomas, Nardini Christine, Frosini Andrea, Osmani Venet, Ballensiefen Wolfgang, D'Errico Gianni, Cormio Paola G, Lionis Christos, Paola G Cormio, Wolfgang Ballensiefen, Gianni D’Errico, Venet Osmani, Thomas Neumuth, Andrea Frosini, Christine Nardini, Christos Lionis, Elio Borgonovi, Mauro Turrini   +40 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bioinformatics Workflow for Clinical Whole Genome Sequencing at Partners HealthCare Personalized Medicine [PDF]

, 2016
Effective implementation of precision medicine will be enhanced by a thorough understanding of each patient’s genetic composition to better treat his or her presenting symptoms or mitigate the onset of disease.
Himanshu Sharma, Sharma, Himanshu, Lebo, Matthew, Peter Rossetti, Chiao-Feng Lin, Ellen Tsai, Matthew Lebo, Rossetti, Peter, Graham, Chet, Shakbatyan, Rimma, Jason Evans, Evans, Jason, Rimma Shakbatyan, Tsai, Ellen A., Lin, Chiao-Feng, Chet Graham   +15 more
core   +1 more source

How to teach person-centered medicine during the coronavirus disease 2019 pandemic? [PDF]

, 2022
Personalized medicine refers to sophisticated diagnostic and therapeutic interventions tailored to the patient’s individual needs. The development of personalized medicine in the last two decades created a global movement of person-centered medicine ...
Klarica, Marijan, Orešković, Slavko, Đordević, Veljko, Pjevač, Neda, Kaštelan, Snježana, Braš, Marijana, Slavko Orešković, Marijana Braš, Neda Pjevač, Veljko Đordević, Snježana Kaštelan, Marijan Klarica   +11 more
core   +1 more source

Artificial Intelligence toward Personalized Medicine

Pharmaceutical Sciences and Research, 2021
In current medical practice when a patient feels symptoms he/she would consult the doctor. The doctor then gives medication in a one-fits-all fashion.
Muhammad Wildan Gifari, Pugud Samodro, Dhadhang Wahyu Kurniawan   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacogenomics and Personalized Medicine in Mood Disorders

, 2013
Pharmacogenomics and the search for personalized medicine focus on the attainment of individualized pharmacotherapies that cover genetic variation and target groups of patients that present neurodevelopmental aspects of symptom profiles and biomarkers ...
Serafino Ricci, Archer, Trevor,, Rapp-Ricciardi, Max,, Max Rapp Ricciardi, Trevor Archer, Ricci, S   +5 more
core   +2 more sources