Results 51 to 60 of about 2,903,093 (261)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2009 Pharmacogenetics has its roots in the 1950s with pioneering studies of monogenic variations in drug metabolism and pharmacokinetics. With the availability of high-throughput genomics technologies and the completion of the Human Genome Project in 2003, we
core +1 more source
Patient-Derived Organoids of Colorectal Cancer: A Useful Tool for Personalized Medicine
, 2022 Colorectal cancer is one of the most important malignancies worldwide, with high incidence and mortality rates. Several studies have been conducted using two-dimensional cultured cell lines; however, these cells do not represent a study model of patient ...
Takumi Kiwaki +3 more
core +1 more source
The forthcoming era of precision medicine [PDF]
Acta Medica Academica, 2016 . The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application.
Stjepan Gamulin
doaj +1 more source
Beyond Personalized Medicine [PDF]
Personalized Medicine, 2009 hope [1]. The aim of this article is to illustrate the path of pharmacogenomics through Seige’s cycle, from euphoria to disappointment. On this basis, I argue for the necessity of a more holistic view of individualized medicine without equating it to pharmacogenomics.
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Acknowledgement to Reviewers of the Journal of Personalized Medicine in 2014
, 2015 The editors of the Journal of Personalized Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Journal of Personalized Medicine Editorial Office
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Personalized Medicine: A Personal View
Current Oncology, 2010 After the discovery of the breast cancer–associated genes BRCA1 in 1994 and BRCA2 in 1995, genetic testing was introduced into clinical practice in North America and Europe[...]
openaire +2 more sources
Biobanks and personalized medicine [PDF]
Clinical Genetics, 2014 AbstractWe provide a mini‐review of how biobanks can support clinical genetics in the era of personalized medicine. We discuss types of biobanks, including disease specific and general biobanks not focused on one disease. We present considerations in setting up a biobank, including consenting and governance, biospecimens, risk factor and related data ...
J E, Olson +6 more
openaire +2 more sources