Results 51 to 60 of about 627,364 (295)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Personalized Critical Care Medicine (Review)

Общая реаниматология, 2022
Personalized medicine (PM) is a major trend in health care development in the 21st century. This area includes studying risk factors for disease development (prediction), interventions for preventing diseases (prophylaxis), individualization of diagnosis
A. M. Golubev
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies. [PDF]

, 2012
BackgroundThe advent of personalized medicine requires robust, reproducible biomarkers that indicate which treatment will maximize therapeutic benefit while minimizing side effects and costs.
Boutros, Paul C, Der, Sandy D, John, Thomas, Jurisica, Igor, Lambin, Philippe, Pintilie, Melania, Shepherd, Frances A, Starmans, Maud Hw, Tsao, Ming-Sound   +8 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings [PDF]

, 2016
Recently, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) initiative to address two major challenges facing the field of psychiatry: (1) the lack of new effective personalized treatments for psychiatric ...
Allen, J, Fonagy, P, Fowler, C, Frueh, BC, Kosten, T, Madan, A, Matthew, S, Nielsen, D, Oldham, J, Salas, R, Sharp, C   +10 more
core   +1 more source

Translational and Personalized Medicine

Medicine, Law & Society, 2015
The idea behind personalized medicine is to tailor health care to an individual’s unique genetic makeup. Hitherto, “one size fits all” approach was used in medicine. With the rise of personal medicine, we are moving towards a more precise, predictable and powerful medicine that is customized for each individual patient.
Kraljević-Pavelić, Sandra, Martinović, Tamara, Pavelić, Krešimir   +2 more
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

PERSONALIZED PHARMACOTHERAPY IN PSYCHIATRY [PDF]

, 2009
The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine.
Anamarija Petek, Pavo Filaković
core   +1 more source

Nutraceutical-based integrative medicine: adopting a mediterranean diet pyramid for attaining healthy ageing in veterans with disabilities [PDF]

, 2018
Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans.
Aiello, Paola, Buccolieri, Cosimo, Catasta, Giovina, Ciccotti, Mario, Lista, Florigio, Palmery, Maura, Peluso, Ilaria, Raguzzini, Anna, Reggi, Raffaella, Sciarra, Tommaso   +9 more
core   +1 more source