Results 191 to 200 of about 613,460 (341)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

ICU Recovery Interventions: Is It Time for a Personalized Medicine Approach? [PDF]

Am J Respir Crit Care Med
Hope AA, McPeake J.
europepmc   +1 more source

Personalized Medicine: The Future of Cancer Treatment

, 2014
S Sarode, G Sarode, S Karmarkar, J Tupkari, S Sarode, G Sarode, J Tupkari, S Sarode, G Sarode, S Sarode, G Sarode, A Patil, S Sarode, G Sarode, G Sarode, S Sarode, S Karmarkar, G Sarode, S Sarode, G Sarode, S Sarode, S Sarode, G Sarode, S Karmarkar   +23 more
openalex   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Advances in cancer immunotherapy and future directions in personalized medicine. [PDF]

Open Life Sci
Wang Y.
europepmc   +1 more source

Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women

, 2019
Natalie A. Bello, Eliza C. Miller, Kirsten Cleary, Ronald J. Wapner   +3 more
openalex   +2 more sources

Promise of personalized omics to precision medicine [PDF]

, 2012
Rui Chen, M Snyder
openalex   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Digital twin for personalized medicine development. [PDF]

Front Digit Health
Saratkar SY, Langote M, Kumar P, Gote P, Weerarathna IN, Mishra GV.   +5 more
europepmc   +1 more source

Esophageal 3D Culture Systems as Modeling Tools in Esophageal Epithelial Pathobiology and Personalized Medicine [PDF]

, 2018
Kelly A. Whelan, Amanda B. Muir, Hiroshi Nakagawa   +2 more
openalex   +1 more source