Results 111 to 120 of about 2,666,075 (354)
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
Deep Active Learning for Dialogue Generation
, 2017 We propose an online, end-to-end, neural generative conversational model for open-domain dialogue. It is trained using a unique combination of offline two-phase supervised learning and online human-in-the-loop active learning.
Asghar, Nabiha +3 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
IEEE AccessAccessibility and inclusion are fundamental human rights, enacted to ensure that everyone has equal access to digital content. However, in practice, a large number of interactive systems remain inaccessible, which prevents users from accessing essential ...
Paula Alexandra Silva +1 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Reformas laborales de mercado y desempleo: enseñanzas de la experiencia de los países de la OCDE [PDF]
(Disponible en idioma inglés únicamente) El mercado laboral de la OCDE ha experimentado cambios importantes en las últimas dos décadas. El más evidente de esos cambios ha sido el aumento del número de personas en busca de empleo.
Stefano Scarpetta
core
Administración de Recursos Humanos : La Empresa y las Personas [PDF]
, 2016 El presente trabajo cuyo tema general es la Administración de Recursos Humanos, está enmarcado en la empresa y las personas. El objetivo general es describir la relación entre la organización y las personas a través de una investigación documental para ...
Guido Téllez, Rosa Ivania +1 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Las personas con discapacidad... vivencian emociones [PDF]
, 2013 Màster en Educació Emocional i Benestar, Facultat de Pedagogia, Departament de Mètodes d’Investigació i Diagnòstic en Educació, Universitat de Barcelona, curs: 2010-2011,La publicació parteix de la idea de que si las emocions són estats del subjecte, les
Valenzuela Sabat, Elena
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