Results 131 to 140 of about 60,293 (261)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Access to public healthcare services for transgender people: experiences in Brazil's capital. [PDF]

Rev Esc Enferm USP
Oliveira EM, Porcino C, Suto CSS, Coelho HT, Antunes PB, Silva DO, Marques PAM, Bampi LNS.   +7 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

[Preventive and therapeutic dental care for people with various disabilities in Argentina] [PDF]

Rev Fac Cien Med Univ Nac Cordoba
Izurieta G, González H, Pinto O, Brunotto M.   +3 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing Customized Personas to Capture Intrinsic Capacity Profiles and Digital Monitoring Intentions in Older Adults: Mixed Methods Study. [PDF]

JMIR Aging
Xuan Z, Niu Y, Kang R, Xiao Q, Jin S, Zhao J, Wang Y, Chang H.   +7 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patient personas of delayed healthcare-seeking behavior among patients with breast cancer-related lymphedema: A qualitative study. [PDF]

Asia Pac J Oncol Nurs
Wang L, Yan S, Xiao R, Chen Y, Cai T, Huang Q, Yang Y, Yuan C.   +7 more
europepmc   +1 more source

Personas que conectan con personas :

En Publicidad y Relaciones Públicas, no basta con saber comunicar; hay que conectar. La Inteligencia Emocional es una competencia clave en este ámbito, pero su enseñanza sigue siendo una asignatura pendiente en la universidad. Para abordar esta carencia, se diseña un manual educativo que integra la Inteligencia Emocional como una competencia esencial ...
openaire   +1 more source