Results 111 to 120 of about 2,796,276 (306)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mecanismo elevador de personas [PDF]
, 2016 El PFC desarrollado a continuación es un trabajo que define un artilugio destinado a ayudar a incorporar a personas que han caído al suelo, elevándolas hasta una altura suficiente que permita que puedan descansar sobre un asiento. En una primera etapa
Ordiales Espada, Miguel
core
Deep Active Learning for Dialogue Generation
, 2017 We propose an online, end-to-end, neural generative conversational model for open-domain dialogue. It is trained using a unique combination of offline two-phase supervised learning and online human-in-the-loop active learning.
Asghar, Nabiha +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mining Impersonification Bias in LLMs via Survey Filling
InformationIn this paper, we introduce a survey-based methodology to audit LLM-generated personas by simulating 200 US residents and collecting responses to socio-demographic questions in a zero-shot setting.
Marco Bombieri, Marco Rospocher
doaj +1 more source
Mediating Informal Care Online: Findings from an Extensive Requirements Analysis [PDF]
Interaction Design and Architecture(s), 2015 Organizing and satisfying the increasing demand for social and informal care for older adults is an important topic. We aim at building a peer-to-peer exchange platform that empowers older adults to benefit from receiving support for daily activities and
Christiane Moser +3 more
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Políticas de la Memoria, 2017 Las historias del activismo gltb que más circulan en Argentina, las que se plasman en libros, documentales, en el relato folklórico que pasa de boca en boca entre activistas y en el relato popular que recibe la sociedad en general, así como buena parte de los estudios académicos, se escriben principalmente en clave gay.[1] Hay casi una épica gay ...
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source