[Comprehensive care of patients with type 1 diabetes in primary health care: policies, practices, and the role of civil societyAtenção integral a pacientes com diabetes tipo 1 na atenção primária à saúde: políticas, práticas e o papel da sociedade civil]. [PDF]
Rangel-Osuna F +2 more
europepmc +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Acelerar la integración de las enfermedades no transmisibles en la atención primaria de salud. [PDF]
da Silva JB.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Using personas and journey maps as knowledge translation tools to enhance clinicians' interpretation of PROM scores. [PDF]
Kwon JY +4 more
europepmc +1 more source
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Integrating NLP and expert validation: a framework combining subjective and objective approaches for female-oriented automotive personas on social media. [PDF]
Bao Q, Zhu Q.
europepmc +1 more source
Mas felicidad para un mayor numero de personas: ¿Es posible esto en México?
Ruut Veenhoven
openalex +1 more source

