Results 211 to 220 of about 2,782,172 (355)

Personas adultas mayores como dinamizadoras sociales. Un proyecto de intervención sociodeducativa desde la universidad [PDF]

, 2017
Cárdenas Rodríguez, Rocío, Rebolledo Gámez, Teresa   +1 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial. [PDF]

NPJ Digit Med
Geraci J, Qorri B, Tsay M, Cumbaa C, Leonczyk P, Alphs L, Ballard ED, Zarate CA, Pani L.   +8 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Consumer personas for CPAP purchasing in older adults with obstructive sleep apnea: a hospital database study. [PDF]

Future Sci OA
Sawunyavisuth B, Suntrawanichakul S, Heingraj S, Amornpan S, Sawanyawisuth K.   +4 more
europepmc   +1 more source

Soporte social con el uso de las TIC para cuidadores de personas con enfermedad crónica: un estado del arte

, 2010
Diana Carolina Cárdenas-Corredor, Brigitte Melenge-Díaz, Johanna Pinilla, Gloria Mabel Carrillo González, Lorena Chaparro-Díaz   +4 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

[Management of type 2 diabetes mellitus in frail patients from the Perspective of Real-World Clinical Practice]. [PDF]

Aten Primaria
Miñana-Castellanos M, Ramon Granés M, Fernández Camins B, Navas Méndez E, Barrot de la Puente J, Lapena Estella C.   +5 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Inpatient Participation in Patient Safety Behaviors: Decision-Making Typologies from a Qualitative Study. [PDF]

Risk Manag Healthc Policy
Wang C, Shi H, Du X, Peng Y, Xiao M, Zhao Q, Huang H.   +6 more
europepmc   +1 more source