Results 61 to 70 of about 2,419,473 (338)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
From Persona to Techsona [PDF]
, 2013 In this paper we introduce the notion of techsona, as a possible counterpart design instrument to personas. We use a case study to illustrate a design process where techsonas help pinpoint technological ideas and alternatives and analyze these systematically.
Bødker, Susanne +1 more
openaire +3 more sources
Too Cool at School - Understanding Cool Teenagers [PDF]
, 2012 Cool can be thought about on three levels; the having of cool things, the doing of cool stuff and the being of cool. Whilst there is some understanding of cool products, the concept, of being cool is much more elusive to designers and developers of ...
Fitton, Daniel +4 more
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2018 This chapter asks what room is there for stand-up comedy as social critique in a ‘post-abjection’ society. In a society where a New Left politics is normative, ‘common sense’, where does this leave radical critique for stand-up comedians? If New Left ideals are mainstream ‘political sense’, how do comedians face up to the obligations of New Left ...
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Designs, 2020 Design is about understanding the system and its users. Although User Experience (UX) research methodologies aim to explain the benefits of a holistic measurement approach including explicit (e.g., self-reported) and implicit (e.g., automatic and ...
Juliana Alvarez +5 more
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Las leyes fundamentales de la estupidez humana
Cuadernos de Economía, 1996 La humanidad se encuentra -y sobre esto el acuerdo es unánime- en un estado deplorable. Ahora bien, no se trata de ninguna novedad. Si uno se atreve a mirar hacia atrás, se da cuenta de que siempre ha estado en una situación deplorable.
Cipolla Carlo M.
doaj
Using System Analysis and Personas for e-Health Interaction Design [PDF]
, 2009 Today, designers obtain more central roles in product and service development (Perks, Cooper, & Jones, 2005). They have to deal with increasingly complicated problems, like integrating the needs of various stakeholders while taking care about social ...
Bredies, Katharina
core