Results 121 to 130 of about 11,092,170 (326)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Fishery Production and Development Perspective of Nepal [PDF]

, 2017
Peifen Zhuang, Amogh Ghimire, N Gautam, E Austreng, T Storebakken, T sgrd, P Zhuang, A Ghimire   +7 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Emerging carbapenemases: a global perspective

, 2010
Timothy R. Walsh
openalex   +2 more sources

Perspective [PDF]

Anesthesiology, 2012
openaire   +2 more sources

Underemployment : a skills utilisation perspective [PDF]

, 2013
More than half of all employees believe that the skills they possess are higher than those required to do their present jobs. This is one of several findings reported in a research paper on "under-employment" in the current edition of the University of ...
Sutherland, John
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Stefan Bürger, Bruno Klein éd., en collaboration avec Katja Schröck, Werkmeister der Spätgotik : I, Position und Rolle der Architekten im Bauwesen des 14. bis 16. Jahrhunderts ; II, Personen, Amt und Image, Darmstadt, Wissenschaftliche Buchgesellschaft, 2009 et 2010

Perspective, 2013
Rédaction de Perspective
doaj   +1 more source

МЕТОДИЧЕСКИЙ ПОДХОД К ФОРМИРОВАНИЮ ОБЛИКА И ПОСТРОЕНИЮ БАЗ ДАННЫХ АВТОМАТИЗИРОВАННОЙ СИСТЕМЫ БЕЗОПАСНОГО СОПРОВОЖДЕНИЯ РЕАЛИЗАЦИИ НАЦИОНАЛЬНЫХ ИНТЕРЕСОВ

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015
В процессе исследований было определено основные и специальные функции автоматизированной экспертно-аналитической системы (АЭАС), сформировано схему организации функции моделирования в АЭАС.
Volodymyr Y. Bohdanovych, Andrii L. Vysidalko   +1 more
doaj  

Ecological Assembly Rules: Perspectives, Advances, Retreats

, 2000
J. Stephen Brewer
openalex   +2 more sources