Results 101 to 110 of about 11,092,170 (326)
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Effective communication, collaboration, and coordination in eXtreme Programming: Human‐centric perspective in a small organization [PDF]
Deepti Mishra, Alok Mishra
openalex +1 more source
An insider perspective of lifelong learning in Singapore: beyond the economic perspective [PDF]
This study traces the learning journeys of a group of people who overcame economic, social and/or educational disadvantages to engage in lifelong learning in Singapore.
Ng, Siew Kheng
core
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Zero-Shot Learners for Natural Language Understanding via a Unified Multiple Choice Perspective [PDF]
Ping Yang +8 more
openalex +1 more source
In perspective: Tom Nairn [PDF]
The 1960s saw an upsurge of separatist nationalisms at the core of the capitalist system, with the movements in Catalonia, Eskudai, Occitania, Quebec, Scotland, Wallonia and Wales all making their first serious impact during that decade.
Davidson, Neil
core
Feature Selection: A Data Perspective
Feature selection, as a data preprocessing strategy, has been proven to be effective and efficient in preparing data (especially high-dimensional data) for various data mining and machine learning problems.
Cheng, Kewei +6 more
core +1 more source

