Results 131 to 140 of about 14,354,690 (343)

Animal models of hospital-acquired pneumonia: current practices and future perspectives

, 2017
Kenny Bielen, Bart ‘s Jongers, Surbhi Malhotra‐Kumar, Philippe G. Jorens, Herman Goossens, Samir Kumar‐Singh   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Perspectives of health practitioners and the key population on predictors of relapse in physical activity and dietary behavior: a concept mapping study [PDF]

, 2020
Eline Roordink, Ingrid HM Steenhuis, Willemieke Kroeze, Mai J. M. Chinapaw, Maartje M. van Stralen   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Behavioral risk assessment in HIV Vaccine Trials Network (HVTN) clinical trials: A qualitative study exploring HVTN staff perspectives

, 2013
Michele P. Andrasik, Shelly Karuna, Michelle Nebergall, Beryl A. Koblin, J. Kublin   +4 more
openalex   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

THE WAYS OF IMPROVING METHODICAL BASIS AND INSTRUMENTAL TOOLS OF DECISION MAKING PROCESSES SUPPORT WITHIN THE NATIONAL SECURITY SYSTEM

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015
During researches is proposed the model of the automated decision-making from substantiate of the strategic objectives for the subjects of the national security system (NSS).
Volodymyr Y. Bohdanovych, Andrii L. Vysidalko, Oleksandr M. Kosohov   +2 more
doaj  

A Study on the Production Characteristics of Media Contents from the Perspective of Relational Dissemination- A Case Study of Social Media [PDF]

, 2016
Juan Yao
openalex   +1 more source

An Analysis of English Learning in Chinese Higher Education from the Perspective of Linguistic Imperialism

, 2021
Danyang Xu
openalex   +2 more sources