Results 101 to 110 of about 4,695,270 (328)

¿Qué es calidad de vida para un paciente con cáncer?

open access: yesAvances en Psicología Latinoamericana, 2015
Objective: To evaluate the concept of quality of life from the patient´s perspective. Method: 1029 patients having different diagnoses of cancer were evaluated using an open-ended question (How would you define Quality of Life?).
Ricardo Sánchez   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Modeling dependent gene expression

open access: yes, 2012
In this paper we propose a Bayesian approach for inference about dependence of high throughput gene expression. Our goals are to use prior knowledge about pathways to anchor inference about dependence among genes; to account for this dependence while ...
Freedman, Ralph S.   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

An omics perspective on drug target discovery platforms

open access: yesBriefings Bioinform., 2019
The drug discovery process starts with identification of a disease-modifying target. This critical step traditionally begins with manual investigation of scientific literature and biomedical databases to gather evidence linking molecular target to ...
J. Paananen, V. Fortino
semanticscholar   +1 more source

Natural Selection: A Stethoscopic Amphibious Installation. [PDF]

open access: yes, 2005
This paper discusses emergence as a complex behaviour in the sound domain and presents a design strategy that was used in the creation of the sound installation Natural Selection to encourage the perception of sonic emergence. The interactions in Natural
Davis, Thomas, Rebelo, P.
core  

Bayesian forecasting and scalable multivariate volatility analysis using simultaneous graphical dynamic models

open access: yes, 2016
The recently introduced class of simultaneous graphical dynamic linear models (SGDLMs) defines an ability to scale on-line Bayesian analysis and forecasting to higher-dimensional time series.
Gruber, Lutz F., West, Mike
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Insights into functional polymer-based organic-inorganic nanocomposites as leather finishes

open access: yesJournal of Leather Science and Engineering, 2019
Nowadays, the increasing demands from consumer challenges the traditional leather products. Traditional polymer leather finishes gradually lose their dominant position in the market.
Qianqian Fan, Jianzhong Ma, Qunna Xu
doaj   +1 more source

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