Results 81 to 90 of about 94,535 (296)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
RALph: A Graphical Notation for Resource Assignments in Business Processes [PDF]
, 2015 The business process (BP) resource perspective deals with the management of human as well as non-human resources throughout the process lifecycle. Although it has received increasing attention recently, there exists no graphical notation for it up until ...
Antonio Ruiz-Cortés +14 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A network perspective on sexual scripts
, 2023 This project uses Gaussian graphical models to gain a new perspective on sexual ...
Timothy J. Luke, Fanny Habacht
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Identification of Monetary Policy in SVAR Models: A Data-Oriented Perspective [PDF]
This paper applies graphical modelling theory to recover identifying restrictions for the analysis of monetary policy shocks in a VAR of the US economy.
Matteo Fragetta, Giovanni Melina
core
Distortion in Perspective Projection
, 2019 The paper presents a unique approach in associating perspective projection with the image beheld by the eye and demonstrates that all graphical and photographic perspective projections must contain distortion when compared to the image beheld by the ...
Kelso Sr., Robert P.
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Generic Graphical Specification Environment for Security Protocol Modelling [PDF]
, 2000 Designing and implementing security protocols is a diÆcult task. A graphical specification environment helps one to cope with this complexity by enabling the visualization of hierarchical message structure and providing suitable abstraction and ...
Hutchison, Dr Andrew +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source