Results 61 to 70 of about 90,912 (255)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Visualizing Three-Qubit Entanglement
EntropyWe present a graphical framework to represent entanglement in three-qubit states. The geometry associated with each entanglement class and type is analyzed, revealing distinct structural features.
Alfred Benedito, Germán Sierra
doaj +1 more source
Graphic-digital expression: a perspective
Estoa, 2013 El uso del ordenador como herramienta efectiva de diseño en el campo de la arquitectura ha sido tema de discusión desde hace décadas. El análisis conjunto y ordenado para establecer una correcta pedagogía, aplicación, investigación y desarrollo tecnológico ha dado lugar a diversas organizaciones, como por ejemplo la Asociación para el Diseño Asistido ...
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Tajik Segment of Social Media: Code-Switching and Graphical Evolution
Виртуальная коммуникация и социальные сетиAs the digital environment transforms the Tajik language, it turns into a new hybrid functional style that diverges from literary standards. The article describes the graphical evolution of digital Tajic, as well as the Russian-Tajik code switching in ...
Iskandarova Diloro
doaj +1 more source
CAD/CAM from the Graphic Design Perspective [PDF]
, 1984 CAD/CAM Systems have evolved elaborate human-computer interfaces in order to facilitate the creation of highly detailed and specialized schematic diagrams and texts. Although these systems have powerful capacities in terms of graphics editing, data manipulation, and data storage, insufficient attention has been given to making the online interface ...
openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source