Results 51 to 60 of about 3,623,148 (283)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effects of Stereoscopic 3D Contents on the Process of Learning to Build a Handmade PC

Knowledge Management & E-Learning: An International Journal, 2011
We previously developed Web3D contents that simulate the procedure for assembling a handmade PC. The original motivation for this project was to enable media-informatics students to deepen their understanding of PC hardware.
Tosh Yamamoto, Toshiya Tsuruoka, Makoto J. Hirayama, Yoshio Yamagishi, Aika Mukai   +4 more
doaj  

REVISITING IDEAL GASES AND PROPOSAL OF A SIMPLE EXPERIMENT FOR DETERMINING ATMOSPHERIC PRESSURE IN THE LABORATORY

Química Nova
Relevant historical aspects concerning ideal gases were briefly reviewed to provide a condensed resource for the undergraduate student of chemistry. The importance of the barometer and the concept of atmospheric pressure were reviewed and discussed.
Leonardo M. Da Silva, Arthur H. de Castro   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Composing high-level stream processing pipelines

Journal of Big Data, 2020
The growing number of Internet of Things (IoT) devices provide a massive pool of sensing data. However, turning data into actionable insights is not a trivial task, especially in the context of IoT, where application development itself is complex.
Tanmaya Mahapatra
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A comparative study of YOLOv5 and YOLOv8 for corrosion segmentation tasks in metal surfaces

Array
This study delves into the comparative efficacy of YOLOv5 and YOLOv8 in corrosion segmentation tasks. We employed three unique datasets, comprising 4942, 5501, and 6136 images, aiming to thoroughly evaluate the models’ adaptability and robustness in ...
Edmundo Casas, Leo Ramos, Cristian Romero, Francklin Rivas-Echeverría   +3 more
doaj   +1 more source

Utilisation de plans forestiers XVIIIe- XIXe siècles pour une étude archéologique des paysages passés de la forêt de Chailluz (Besançon) : l’exemple d’un réseau viaire

Bulletin du Centre d’Études Médiévales d’Auxerre, 2015
Today Besancon has the highest percentage of green space per inhabitant among France’s largest cities (200 m2 per capita). 3/4 of it are made up by the Forêt de Chailluz (16.7 km2), a large forest which has maintained its present extent for over six ...
Catherine Fruchart
doaj   +1 more source

Think Spatially With Game Engine

ISPRS International Journal of Geo-Information, 2020
Spatial thinking and spatial orientation skills are involved in tasks related to the recognition of landforms, mapping, spatial interpretation, and landscape analysis, and can be developed with specific training.
Carlos Carbonell-Carrera, Peri Gunalp, Jose Luis Saorin, Stephany Hess-Medler   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source