Results 71 to 80 of about 3,623,148 (283)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Insights into functional polymer-based organic-inorganic nanocomposites as leather finishes

open access: yesJournal of Leather Science and Engineering, 2019
Nowadays, the increasing demands from consumer challenges the traditional leather products. Traditional polymer leather finishes gradually lose their dominant position in the market.
Qianqian Fan, Jianzhong Ma, Qunna Xu
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Visualizing Three-Qubit Entanglement

open access: yesEntropy
We present a graphical framework to represent entanglement in three-qubit states. The geometry associated with each entanglement class and type is analyzed, revealing distinct structural features.
Alfred Benedito, Germán Sierra
doaj   +1 more source

A Common Platform for Graphical Models in R: The gRbase Package [PDF]

open access: yes
The gRbase package is intended to set the framework for computer packages for data analysis using graphical models. The gRbase package is developed for the open source language, R, and is available for several platforms.
Claus Dethlefsen, Søren Højsgaard
core  

Graphic-digital expression: a perspective

open access: yesEstoa, 2013
El uso del ordenador como herramienta efectiva de diseño en el campo de la arquitectura ha sido tema de discusión desde hace décadas. El análisis conjunto y ordenado para establecer una correcta pedagogía, aplicación, investigación y desarrollo tecnológico ha dado lugar a diversas organizaciones, como por ejemplo la Asociación para el Diseño Asistido ...
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Tajik Segment of Social Media: Code-Switching and Graphical Evolution

open access: yesВиртуальная коммуникация и социальные сети
As the digital environment transforms the Tajik language, it turns into a new hybrid functional style that diverges from literary standards. The article describes the graphical evolution of digital Tajic, as well as the Russian-Tajik code switching in ...
Iskandarova Diloro
doaj   +1 more source

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