Results 31 to 40 of about 80,946 (242)

Remote sensing data as a potential source for establishment of the 3d cadastre in Slovenia [PDF]

open access: yesGeodetski Vestnik, 2016
The topic of this paper is the challenges of using remote sensing technologies as one of the potential data sources for the establishment of a 3D real property cadastre in Slovenia. More than a decade ago, the legal basis for the registration of property
Petra Drobež   +3 more
doaj   +1 more source

A Corner-Highlighting Method for Ambient Occlusion

open access: yesApplied Sciences, 2021
Graphical user experiences are now ubiquitous features, and therefore widespread. Specifically, the computer graphics field and the game industry have been continually favoring the ambient occlusion post-processing method for its superb indirect light ...
Sukjun Park, Nakhoon Baek
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Schrift als Komponente der Bildschirmfläche am Beispiel der deutschen Nachrichtensendungen

open access: yesLinguistik Online, 2020
The article focusses the written components of the screen surface in television news programs. The semiotic perspective represented in this article legitimises the viewpoint that they are not (ordinary) language signs. The main concern of this article is
Anna Kapuścińska
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Composing high-level stream processing pipelines

open access: yesJournal of Big Data, 2020
The growing number of Internet of Things (IoT) devices provide a massive pool of sensing data. However, turning data into actionable insights is not a trivial task, especially in the context of IoT, where application development itself is complex.
Tanmaya Mahapatra
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

REVISITING IDEAL GASES AND PROPOSAL OF A SIMPLE EXPERIMENT FOR DETERMINING ATMOSPHERIC PRESSURE IN THE LABORATORY

open access: yesQuímica Nova
Relevant historical aspects concerning ideal gases were briefly reviewed to provide a condensed resource for the undergraduate student of chemistry. The importance of the barometer and the concept of atmospheric pressure were reviewed and discussed.
Leonardo M. Da Silva   +1 more
doaj   +1 more source

Utilisation de plans forestiers XVIIIe- XIXe siècles pour une étude archéologique des paysages passés de la forêt de Chailluz (Besançon) : l’exemple d’un réseau viaire

open access: yesBulletin du Centre d’Études Médiévales d’Auxerre, 2015
Today Besancon has the highest percentage of green space per inhabitant among France’s largest cities (200 m2 per capita). 3/4 of it are made up by the Forêt de Chailluz (16.7 km2), a large forest which has maintained its present extent for over six ...
Catherine Fruchart
doaj   +1 more source

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