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Perturbation-adapted perturbation theory [PDF]
The Journal of Chemical Physics, 2022 A new general approach is introduced for defining an optimum zero-order Hamiltonian for Rayleigh–Schrödinger perturbation theory. Instead of taking the operator directly from a model problem, it is constructed to be a best fit to the exact Hamiltonian within any desired functional form.
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Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2
Nature Communications, 2022 Numerous rationally-designed and directed-evolution variants of SpCas9 have been reported to expand the utility of CRISPR technology. Here the authors make comparisons of numerous Cas9 variants, nominate options for base editing screens with denser ...
Annabel K. Sangree +8 more
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Local perturbations perturb—exponentially–locally [PDF]
Journal of Mathematical Physics, 2015 We elaborate on the principle that for gapped quantum spin systems with local interaction, “local perturbations [in the Hamiltonian] perturb locally [the groundstate].” This principle was established by Bachmann et al. [Commun. Math. Phys. 309, 835–871 (2012)], relying on the “spectral flow technique” or “quasi-adiabatic continuation” [M. B.
De Roeck, Wojciech, Schütz, Marius
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Nature Communications, 2022 Existing methods for generating sgRNA predictions do not account for the tracrRNA sequence. Here the authors report an on-target model, Rule Set 3, to generate optimal predictions for multiple tracrRNA variants, and validate this on a new dataset of ...
Peter C. DeWeirdt +5 more
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BETA EFFECTIVE SENSITIVITY TO NUCLEAR DATA WITHIN THE APOLLO3® NEUTRONIC PLATFORM [PDF]
EPJ Web of Conferences, 2021 In this paper, we present a sensitivity analysis of the beta effective to nuclear data for the UM17x17 experiment that has been performed in the EOLE reactor. This work is carried out using the APOLLO3® platform.
Valocchi G., Archier P., Tommasi J.
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Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications, 2023 Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with ...
Fadi J. Najm +11 more
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Journal of the European Optical Society-Rapid Publications, 2023 The parameter dynamics of super-sech and super-Gaussian pulses for the perturbed nonlinear Schrödinger’s equation with power-law nonlinearity is obtained in this article. The variational principle successfully recovers this dynamical system.
Zayed Elsayed M.E. +10 more
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Nature Communications, 2021 CRISPR-based knockout screens in cancer cells have suggested the existence of proliferation suppressor genes (PSG). Here, the authors develop an approach to systematically identify them, and reveal a PSG module involved in fatty acid synthesis and tumour
W. Frank Lenoir +13 more
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Stop Voicing and F0 Perturbation in Pahari
Acta Linguistica Asiatica, 2021 The present study has been carried out to investigate the perturbation effect of the voicing of initial stops on the fundamental frequency (F0) of the following vowels in Pahari.
Nazia Rashid +3 more
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Flow and Heat Transfer Analysis of the Sodium Alginate Conveying Copper Nanoparticles between Two Parallel Plates [PDF]
Journal of Applied and Computational Mechanics, 2017 In this study, the steady incompressible flow of a non-Newtonian sodium alginate (SA) fluid conveying copper nanoparticles (Cu) which flow within two vertical parallel plates is investigated by using the homotopy perturbation analytical scheme to solve ...
Akin T. Akinshilo +2 more
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