Results 41 to 50 of about 13,036,763 (283)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Modeling of micro flows using perturbation method [PDF]

open access: yes, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Shirani, E   +4 more
core   +5 more sources

On the existence of bound and ground states for some coupled nonlinear Schrödinger–Korteweg–de Vries equations

open access: yesAdvances in Nonlinear Analysis, 2017
We show the existence of positive bound and ground states for a system of coupled nonlinear Schrödinger–Korteweg–de Vries equations. More precisely, we prove that there exists a positive radially symmetric ground state if either the coupling coefficient ...
Colorado Eduardo
doaj   +1 more source

Joint Action and Competition between Centrifugal, Magnetorotational, and Magnetic Buoyancy Instabilities

open access: yesThe Astrophysical Journal Supplement Series, 2023
Instabilities driven by some combination of rotation, velocity shear, and magnetic field in a stratified fluid under gravity play an important role in many astrophysical settings.
M. J. Gradzki   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The perturbation effect in wildlife systems: an emergent property of simple models [PDF]

open access: yes, 2012
Population reduction is often used as a control strategy when managing infectious diseases in wildlife populations, however it disrupts existing social structures and increases movement of infectives due to the vacuum effect, which may lead to enhanced ...
Prentice, Jamie C
core   +5 more sources

Projection Perturbation Methods in Optimization Problems of Controlled Systems

open access: yesИзвестия Иркутского государственного университета: Серия "Математика", 2014
Perturbation methods are used to implement the conditions of nonlocal improvement of controls, constructed in the form of special boundary value problems in space of phase and conjugate variables and in the form of special tasks of a fixed point of ...
A.S. Buldaev
doaj  

Nonlinear oscillations of the absolute elastic weightless string. Asymptotics construction

open access: yesLietuvos Matematikos Rinkinys, 2007
The mathematical model of string nonlinear oscillations is presented. To find the asymptotic solution of the problem an averaging scheme is constructed.
Aleksandras Krylovas, Paulius Miškinis
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The Main Problem of Lunar Orbit Revisited

open access: yesThe Astronomical Journal, 2023
A novel algorithm based on the Lindstedt–Poincaré method is proposed to construct an analytical solution of the lunar orbit. Based on the analytical solution, a numerical fitting algorithm is proposed to improve the coefficients of the analytical ...
Bo-Sheng Li, Xi-Yun Hou
doaj   +1 more source

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