Results 41 to 50 of about 173,772,216 (255)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
LIFE.PTML Model Development Targeting Calmodulin Pathway Proteins
Chemistry ProceedingsDeveloping predictive models for drug efficacy is challenged by the complexity and heterogeneity of bioassay data. Here, we present LIFE.PTML, which is a methodology integrating drug Lifecycle (L), Information Fusion (IF), Encoding (E), Perturbation ...
Maider Baltasar-Marchueta +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Counting and building operators in theories with hidden symmetries and application to HEFT
Journal of High Energy PhysicsIdentifying a full basis of operators to a given order is key to the generality of Effective Field Theory (EFT) and is by now a problem of known solution in terms of the Hilbert series.
Rodrigo Alonso, Shakeel Ur Rahaman
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Generalized quadratic operators and perturbations [PDF]
, 2022 summary:We provide a complete description of the perturbation class and the commuting perturbation class of all generalized quadratic bounded operators with respect to a given idempotent bounded operator in the context of complex Banach spaces ...
Souilah, Khalid
core +1 more source
Well-posedness and stability analysis of hybrid feedback systems using Shkalikov's theory [PDF]
Opuscula Mathematica, 2006 The modern method of analysis of the distributed parameter systems relies on the transformation of the dynamical model to an abstract differential equation on an appropriately chosen Banach or, if possible, Hilbert space.
Piotr Grabowski
doaj
Perturbation Theory of Polynomials and Linear Operators
66 pages. The numbering of equations was changed, and a few more modifications were made. This final version will appear as a chapter in the book series "Handbook of Geometry and Topology of Singularities", Vol ...
Parusiński, Adam, Rainer, Armin
openaire +3 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source