Results 91 to 100 of about 125,197 (248)

Rediscovering Pertussis [PDF]

open access: yesFrontiers in Pediatrics, 2016
Pertussis, caused by Bordetella (B.) pertussis, a Gram-negative bacterium, is a highly contagious airway infection. Especially in infants, pertussis remains a major health concern. Acute infection with B. pertussis can cause severe illness characterized by severe respiratory failure, pulmonary hypertension, leucocytosis, and death. Over the past years,
openaire   +2 more sources

Socioeconomic Risk Factors for Incomplete Vaccination in Swedish Two‐Year‐Olds—A Nationwide, Population‐Based Cohort Study

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim To analyse the association between specific socioeconomic measures and the risk of incomplete vaccination for diphtheria‐tetanus‐pertussis (DTP) and measles‐containing vaccine (MCV) in Swedish two‐year‐olds. Methods This nationwide, population‐based cohort study included 227 457 children born in Sweden during 2014–2015.
Cecilia Chrapkowska Almqvist   +5 more
wiley   +1 more source

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. [PDF]

open access: yes, 2012
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation.
Banigan, Edward J   +11 more
core   +2 more sources

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito   +6 more
wiley   +1 more source

Burden of Pertussis in Individuals with a Diagnosis of Asthma: A Retrospective Database Study in England

open access: yesJournal of Asthma and Allergy, 2022
Amit Bhavsar,1 Emmanuel Aris,2 Lauriane Harrington,3 Jason C Simeone,4 Anna Ramond,5 Dimitra Lambrelli,5 Alberto Papi,6 Louis-Philippe Boulet,7 Kinga Meszaros,8 Nicolas Jamet,8 Yan Sergerie,3 Piyali Mukherjee3 1Europe Medical Affairs, GSK, Wavre, Belgium;
Bhavsar A   +11 more
doaj  

Understanding the Epidemiology of Pertussis in Denmark

open access: yes
Acta Paediatrica, EarlyView.
Tine Dalby   +2 more
wiley   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade   +7 more
wiley   +1 more source

Mathematical Model of Vaccine Noncompliance [PDF]

open access: yes, 2016
Vaccine scares can prevent individuals from complying with a vaccination program. When compliance is high, the critical vaccination proportion is close to being met, and herd immunity occurs, bringing the disease incidence to extremely low levels.
Bauer, Jordan, Capaldi, Alex
core   +2 more sources

Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]

open access: yes, 2011
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun   +3 more
core   +2 more sources

Tissue Resident Memory Cells: Friend or Foe?

open access: yesImmunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude   +2 more
wiley   +1 more source

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