Results 71 to 80 of about 3,335 (157)

Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China

Microorganisms
Background: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system. Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang ...
Hanying Dai, Hanqing He, Juan Xu, Yao Zhu, Tao Fu, Bohan Chen, Jie Li, Yuan Gao, Aiping Qin, Maojun Zhang, Zhujun Shao   +10 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin

Human Vaccines & Immunotherapeutics, 2019
Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade ...
Naveen Surendran, Michael Pichichero
doaj   +1 more source

Association of Pertussis Toxin with Severe Pertussis Disease

Toxins, 2019
Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and multiply extracellularly in the airways and release several toxins, which have
Karen Scanlon, Ciaran Skerry, Nicholas Carbonetti   +2 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Highlights of the 14th International Bordetella Symposium

mSphere
Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis.
Kevin Munoz Navarrete, Kathryn M. Edwards, Kingston H. G. Mills, Jana Kamanová, María Eugenia Rodriguez, Andrew Gorringe, Andrew Preston, Beate Kampmann, Monica C. Gestal, Eric T. Harvill, Purnima Dubey, Dimitri A. Diavatopoulos, Seema Mattoo, Karen M. Scanlon, Camille Locht, Peter Sebo   +15 more
doaj   +1 more source

Understanding the High Incidence of Pertussis in Norway: The Role of Test Activity

Acta Paediatrica, EarlyView.
Margrethe Greve‐Isdahl, Elina Seppälä   +1 more
wiley   +1 more source

Co‐Coverage of Essential Interventions Across the Health System Continuum of Care for Improving Child Nutrition in Ethiopia

Maternal &Child Nutrition, EarlyView.
ABSTRACT This study aimed to assess the coverage of essential nutrition interventions delivered through the health system and explored the relationship between co‐coverage and child‐ and maternal‐level factors, household‐level factors, and access to healthcare facilities.
Alemnesh Petros, Meron Girma, Tsedey Moges, Alemayehu Hussen, Tadesse Kebebe, Meseret Woldeyohannes, Teshome Asefa, Daniel Abera, Yirgalem Tadesse, Getachew Tollera, Mesay Hailu, Arnaud Laillou, Stanley Chitekwe, Kaleab Baye, Ramadhani Noor, Masresha Tessema   +15 more
wiley   +1 more source

Prevention of pertussis: An unresolved problem

Human Vaccines & Immunotherapeutics, 2018
Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis. However, after the introduction of the whole-cell pertussis vaccine (wP), the annual incidence rates of the disease progressively declined.
Susanna Esposito, Nicola Principi
doaj   +1 more source

Tracking Pertussis and Evaluating Control Measures through Enhanced Pertussis Surveillance, Emerging Infections Program, United States

Emerging Infectious Diseases, 2015
Despite high coverage with pertussis-containing vaccines, pertussis remains endemic to the United States. There have been increases in reported cases in recent years, punctuated by striking epidemics and shifting epidemiology, both of which raise ...
Tami H. Skoff, Joan Baumbach, Paul R. Cieslak   +2 more
doaj   +1 more source