Next-Generation Whole-Cell Pneumococcal Vaccine [PDF]
Vaccines, 2019 Streptococcus pneumoniae remains a major public health hazard. Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited ...
Victor Morais +2 more
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Immune Responses to Irradiated Pneumococcal Whole Cell Vaccine [PDF]
Vaccines, 2021 Streptococcus pneumoniae (pneumococcus) can cause respiratory and systemic diseases. Recently, γ-irradiation-inactivated, non-encapsulated, intranasal S.
Eunbyeol Ko +10 more
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Whole-Cell Vaccine Preparation Through Prussian Blue Nanoparticles-Elicited Immunogenic Cell Death and Loading in Gel Microneedles Patches [PDF]
GelsTumor whole-cell vaccines are designed to introduce a wide range of tumor-associated antigens into the body to counteract the immunosuppression caused by tumors.
Wenxin Fu +5 more
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Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model [PDF]
Vaccines, 2023 The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with the risk of therapeutic resistance.
Gábor J. Szebeni +7 more
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Coxiella burnetii Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model [PDF]
Frontiers in Immunology, 2021 Q-VAX®, a whole cell, formalin-inactivated vaccine, is the only vaccine licensed for human use to protect against Coxiella burnetii, the cause of Q fever.
Alycia P. Fratzke +6 more
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A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist
Cells, 2022 A single-protein or -peptide vaccine is not sufficient to arouse immune responses in cancer therapy. A whole-tumor-cell vaccine with complete cancer cell antigens and all conformations elicits robust immune responses and is a promising method for the ...
Huju Chi +8 more
doaj +3 more sources
Comparative Efficacy in Challenge Dose Models of a Toxin Expressing Whole-Cell Vaccine against Eight Serovars of Actinobacillus pleuropneumoniae in Pigs [PDF]
Animals, 2022 Actinobacillus pleuropneumoniae is a major economically significant bacterial respiratory pig pathogen, and whole cell vaccines are used to prevent disease. However, there is little data available on multi-serovar whole cell vaccine protection. Therefore,
Preben Mortensen +5 more
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Indian Journal of Animal Sciences, 2021 In search for better vaccine candidates for Johne's disease, chitosan nanoparticle coupled heat killed whole cell and fusion protein (Antigen 85A+85B) vaccines were developed using a local isolate of Mycobacterium avium subsp.
K VIJAYARANI +4 more
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Adjuvant Effect of Whole-Cell Pertussis Component on Tetanus Toxoid Potency in Murine Model
Biomedicines, 2023 There is currently an increasing interest in the development of new-generation purified antigen-based vaccines with a higher safety profile compared to conventional inactivated vaccines.
Marta Prygiel +4 more
doaj +1 more source
Frontiers in Immunology, 2022 The protocol used to induce cell death for generating vaccines from whole tumor cells is a critical consideration that impacts vaccine efficacy. Here we compared how different protocols used to induce cell death impacted protection provided by a ...
Kyle Seaver +4 more
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