Results 1 to 10 of about 9,690 (111)

Active vaccine safety surveillance: Experience from a prospective cohort event monitoring study of COVID-19 vaccines in Kenya. [PDF]

PLOS Global Public Health
Although active vaccine safety surveillance (VSS) can complement passive VSS while overcoming the inherent limitations of spontaneous safety monitoring, it remains rare in sub-Saharan Africa.
Don B Odhiambo, Donald Akech, Boniface Karia, Makobu Kimani, Samuel Sang, Antipa Sigilai, Shirine Voller, Christine Mataza, David Mang'ong'o, Rose Jalang'o, Martha Mandale, Anthony O Etyang, John Anthony Gerard Scott, Ambrose Agweyu, Eunice Wangeci Kagucia   +14 more
doaj   +2 more sources

A randomized Phase I/II study to evaluate safety and reactogenicity of a heat-stable rotavirus vaccine in healthy adults followed by evaluation of the safety, reactogenicity, and immunogenicity in infants

Human Vaccines and Immunotherapeutics, 2020
Objectives: To assess the safety and reactogenicity of single oral dose of heat-stable rotavirus vaccine (HSRV) in healthy adults aged 18–45 years followed by assessment of safety, reactogenicity, and immunogenicity of three doses of HSRV in healthy ...
Vibhu Kanchan, K Zaman, Warda Haque
exaly   +2 more sources

From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics

Pharmaceuticals, 2023
In biomedical applications, nanomaterial-based delivery vehicles, such as lipid nanoparticles, have emerged as promising instruments for improving the solubility, stability, and encapsulation of various payloads.
Tetiana Korzun, Abraham S Moses, Parham Diba   +2 more
exaly   +3 more sources

Progressive Dissociation Between Reactogenicity and Immunogenicity After Four-Dose BNT162b2 Vaccination: A 36-Month Longitudinal Study [PDF]

Vaccines
Background/Objectives: Understanding the relationship between reactogenicity and immunogenicity after repeated BNT162b2 vaccination is critical for optimizing vaccination strategies.
Sanja Zember, Kristian Bodulić, Nataša Cetinić Balent, Alemka Markotić, Oktavija Đaković Rode   +4 more
doaj   +2 more sources

Generalized Modules for Membrane Antigens (GMMA) Elicit Mild Local Reactogenicity After Intramuscular Injection in Absence of Aluminum Salt Adjuvant [PDF]

Immunity, Inflammation and Disease
Background and Objectives Generalized modules for membrane antigens (GMMA) are outer membrane vesicles derived from gram‐negative bacteria that can be used to design affordable subunit vaccines.
Raffaella Cecchi, Silvia Maccari, Renzo Alfini, Roberta Di Benedetto, Simona Gallorini, Elena Cartocci, Sara Marchi, Giacomo Romagnoli, Erika Bartolini, Francesca Micoli, Diego Piccioli   +10 more
doaj   +2 more sources

The Relationship between Immunogenicity and Reactogenicity of Seasonal Influenza Vaccine Using Different Delivery Methods

Vaccines
Vaccine immunogenicity and reactogenicity depend on recipient and vaccine characteristics. We hypothesized that healthy adults reporting higher reactogenicity from seasonal inactivated influenza vaccine (IIV) developed higher antibody titers compared ...
Daniel J Grömer, Nadine Rouphael, Rouphael Nadine   +2 more
exaly   +3 more sources

Reactogenicity Differences between Adjuvanted, Protein-Based and Messenger Ribonucleic Acid (mRNA)-Based COVID-19 Vaccines

Vaccines
Participants in studies investigating COVID-19 vaccines commonly report reactogenicity events, and concerns about side effects may lead to a reluctance to receive updated COVID-19 vaccinations.
Matthew D Rousculp, Anthony M Marchese, Hadi Beyhaghi   +2 more
exaly   +3 more sources

Burden and Impact of Reactogenicity among Adults Receiving COVID-19 Vaccines in the United States and Canada: Results from a Prospective Observational Study

Vaccines
As SARS-CoV-2 variants continue to emerge, vaccination remains a critical tool to reduce the COVID-19 burden. Vaccine reactogenicity and the impact on work productivity/daily activities are recognized as contributing factors to vaccine hesitancy.
Matthew D Rousculp, Anthony M Marchese, Seth Toback   +2 more
exaly   +3 more sources

Pre-Vaccination Immune Profiles and Responsiveness to Innate Stimuli Predict Reactogenicity and Antibody Magnitude Following mRNA Vaccination [PDF]

Vaccines
Background: While mRNA vaccines effectively limit hospitalization and severe COVID-19 disease, the precise early innate immune mechanisms associated with their efficacy and reactogenicity remain underexplored.
Amanda E. Zelkoski, Emilie Goguet, Emily Samuels Darcey, Mohamad-Gabriel Alameh, Hooda Said, Simon Pollett, John H. Powers, Eric D. Laing, Cara Olsen, Edward Mitre, Allison M. W. Malloy   +10 more
doaj   +2 more sources

Systemic reactogenicity following homologues and heterologous prime-boost AZD1222 and BNT162b2 COVID-19 vaccination of 2862 healthcare workers compared with an unvaccinated population

Vaccine: X, 2023
During spring 2021, AZD1222 and BNT162b2 were used as prime and BNT162b2 as booster COVID-19 vaccines in Denmark. We obtained self-reported information on systemic reactogenicity day-by-day during two weeks for 2862 healthcare workers vaccinated with ...
Sorosh Tabatabaeifar, Jesper M. Vestergaard, Else T. Würtz, Karoline K. Hansen, Kent J. Nielsen, Vivi Schlünssen, Henrik A. Kolstad   +6 more
doaj   +1 more source