Results 1 to 10 of about 1,693,659 (204)
mRNA vaccine for cancer immunotherapy [PDF]
Molecular Cancer, 2021 mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune
Lei Miao, Yu Zhang, Leaf Huang
semanticscholar +4 more sources
PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge
mBioPorcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes severe diarrhea in neonatal piglets, which is associated with a high mortality rate.
Yongxiang Zhao +11 more
doaj +2 more sources
A Thermostable mRNA Vaccine against COVID-19
Cell, 2020 There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19) because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA (mRNA)-based vaccine has emerged as a rapid and versatile platform to quickly respond to ...
Chao Zhou +2 more
exaly +2 more sources
Recent Advancement in mRNA Vaccine Development and Applications
Pharmaceutics, 2023 Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic efficacy in various applications, including infectious disease, immunotherapy, genetic
Fahad Almughem +2 more
exaly +2 more sources
Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications
Virology JournalMessenger RNA (mRNA) vaccines have emerged as a transformative platform in modern vaccinology. mRNA vaccine is a powerful alternative to traditional vaccines due to their high potency, safety, and efficacy, coupled with the ability for rapid clinical ...
Chit-Laa Poh
exaly +2 more sources
Nature CommunicationsmRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of mRNA vaccines by generating a comprehensive single-cell transcriptome ...
Seongryong Kim +15 more
doaj +2 more sources
Developing mRNA-vaccine technologies [PDF]
RNA Biology, 2012 mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity while not subject to MHC haplotype restriction.
Thomas Schlake +2 more
exaly +3 more sources
Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine [PDF]
The Journal of Clinical InvestigationAlthough virus-like particle (VLP) vaccines were shown to be effective against several viruses, their advantage over vaccines that include envelope protein only is not completely clear, particularly for mRNA-encoded VLPs.
Chandru Subramani +10 more
doaj +2 more sources
mRNA vaccine designs for optimal adjuvanticity and delivery
RNA BiologyAdjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the co-delivery of antigen mRNA and adjuvants in a unified, all-in-one formulation.
Yuki Mochida, Satoshi Uchida
doaj +2 more sources
Nature CommunicationsmRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from H5 clade 2.3.
Colleen Furey +16 more
doaj +2 more sources