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Vaccines, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection.
Frank Kowalzik +5 more
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Multi-epitope mRNA vaccine and protein vaccine protect mice against Toxoplasma gondii [PDF]
Parasites & VectorsBackground Toxoplasma gondii, an obligate intracellular protozoan parasite, infects almost one-third of the world’s population and all warm-blooded animals, posing a substantial threat to public health.
Yulin Cui +6 more
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Frontiers in Public Health, 2023 IntroductionEpidemiological modeling is widely used to offer insights into the COVID-19 pandemic situation in Asia. We reviewed published computational (mathematical/simulation) models conducted in Asia that assessed impacts of pharmacological and non ...
Karan Thakkar +6 more
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In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
Vaccines, 2023 mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov +3 more
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Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
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Industrial Psychiatry Journal, 2021 “Necessity is the mother of invention:” An adage was brought to life with the emergence of the mRNA vaccine against the backdrop of the foreboding and mercurial COVID-19 pandemic. Considering a negligible adverse-effect profile and a break-neck manufacturing speed, it shone bright as the ideal vaccine candidate.
Tahoora Ali +4 more
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Emergence of mRNA vaccines in the management of cancer
Expert Review of Vaccines, 2023 Introduction mRNA vaccines have been developed as a promising cancer management. It is noted that specification of the antigen sequence of the target antigen is necessary for the design and manufacture of an mRNA vaccine. Areas covered The steps involved
Mohamad Irfan Mohamad Razif +8 more
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Vaccines, 2022 Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here,
Eli Magen +12 more
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mRNA as a Therapeutics: Understanding mRNA Vaccines
Advanced Pharmaceutical Bulletin, 2021 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
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From mRNA sensing to vaccines [PDF]
Immunity, 2021 The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
Fauci, Anthony S. +8 more
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