Results 41 to 50 of about 912,051 (307)

New diagnosis of multiple sclerosis in the setting of mRNA COVID-19 vaccine exposure

, 2022
Background: Multiple sclerosis (MS) with onset in the setting of acute SARS-CoV-2 virus infection has been reported, and reactivation of MS following non-mRNA COVID-19 vaccination has been noted, but there have only been three reports of newly diagnosed ...
Toljan, K, Kunchok, A, Amin, M, Ontaneda, D   +3 more
core   +1 more source

Duration of COVID-19 mRNA Vaccine Effectiveness against Severe Disease [PDF]

, 2022
Waning immunity following administration of mRNA-based COVID-19 vaccines remains a concern for many health systems. We undertook a study to determine if recent reports of waning for severe disease could have been attributed to design-related bias by ...
Jesha M. A. Mundodan, Bertollini, Roberto, Mundodan, Jesha M. A., Al-Romaihi, Hamad Eid, Jazeel Abdulmajeed, Maha H. M. A. Al-Shamali, Mundodan, Jesha M.A., Anvar H. Kaleeckal, Farag, Elmobashar, Rekayahouda Baaboura, Farhan S. Cyprian, Soha S. A. Albayat, Albayat, Soha S.A., Kaleeckal, Anvar H., Mohamed Ghaith Al-Kuwari, Abdullatif Al Khal, Cyprian, Farhan S., Tawanda Chivese, Bansal, Devendra, Al-Shamali, Maha H.M.A., Kandy, Mujeeb C., Doi, Suhail A.R., Doi, Suhail A. R., Hayat S. Khogali, Sayed M. Himatt, Al-Kuwari, Mohamed Ghaith, Mohamed Hamad Al-Thani, Elmobashar Farag, Hamad Eid Al-Romaihi, Latif, Ali Nizar, Khogali, Hayat S., Devendra Bansal, Al-Shamali, Maha H. M. A., Abdulmajeed, Jazeel, Suhail A. R. Doi, Baaboura, Rekayahouda, Roberto Bertollini, Albayat, Soha S. A., Chivese, Tawanda, Mujeeb C. Kandy, Al Khal, Abdullatif, Al-Thani, Mohamed Hamad, Himatt, Sayed M., Ali Nizar Latif   +43 more
core   +1 more source

mRNA vaccines for cancer immunotherapy

Frontiers in Immunology, 2022
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA vaccines are an attractive and powerful immunotherapeutic platform against cancer because of their high potency, specificity, versatility, rapid and large-scale development capability, low-cost manufacturing potential, and safety.
Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan   +4 more
openaire   +3 more sources

Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits

Frontiers in Immunology
IntroductionSyphilis is a sexually or vertically transmitted disease caused by the infection of Treponema pallidum (T. pallidum). Syphilis prevalence has risen globally despite the availability of effective treatments.
Zhiyu Lu, Yizhou Lu, Di Liu, Fangzhi Du, Qingyun Wu, Guoyang Liao, Yanan Wu, Rui-Li Zhang, Jian Zhou, Qianqiu Wang   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The advances of adjuvants in mRNA vaccines

npj Vaccines, 2023
AbstractThe remarkable success of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has propelled the rapid development of this vaccination technology in recent years. Over the last three decades, numerous studies have shown the considerable potential of mRNA vaccines that elicit protective immune ...
Chunyuan Xie, Ruhui Yao, Xiaojun Xia
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A 5-year follow-up of antibody response in children vaccinated with single dose of live attenuated SA14-14-2 Japanese encephalitis vaccine: immunogenicity and anamnestic responses

, 2008
Out of 98 subjects who had participated in the 2000 JE vaccination campaign, 69 people were enrolled in the tests of 2004 and 2005 for the evaluation of long term immune response of a single dose of live attenuated SA14-14-2 JE vaccine.
오희철
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The mRNA vaccine, a swift warhead against a moving infectious disease target

Expert Review of Vaccines
Introduction The rapid development of mRNA vaccines against SARS-CoV-2 has revolutionized vaccinology, offering hope for swift responses to emerging infectious diseases.
Sheema Mir, Mohammad Mir
doaj   +1 more source