Results 51 to 60 of about 1,693,659 (204)

Formulation development of a stable influenza recombinant neuraminidase vaccine candidate

Human Vaccines & Immunotherapeutics
Current influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy.
Bing Li, Irina V. Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y. Y. Fung, Guadalupe Cortés, D. Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H. Brookes, Salvador F. Ausar   +11 more
doaj   +1 more source

Adverse events following COVID‐19 mRNA vaccines: A systematic review of cardiovascular complication, thrombosis, and thrombocytopenia

Immunity, Inflammation and Disease, 2023
Background and Objectives Since publishing successful clinical trial results of mRNA coronavirus disease 2019 (COVID‐19) vaccines in December 2020, multiple reports have arisen about cardiovascular complications following the mRNA vaccination. This study
Farah Yasmin, Hala Najeeb, Unaiza Naeem, Abdul Moeed, Abdul Raafe Atif, Muhammad Sohaib Asghar, Nayef Nimri, Maryam Saleem, Dhrubajyoti Bandyopadhyay, Chayakrit Krittanawong, Mohammed Mahmmoud Fadelallah Eljack, Muhammad Junaid Tahir, Fahad Waqar   +12 more
doaj   +1 more source

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

medRxiv, 2022
Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle mRNA vaccines for SARS-CoV-2 contain small amounts of PEG but it is not known if PEG antibodies are enhanced by vaccination and if ...
Yi Ju, W. Lee, Emily H. Pilkington, Hannah G. Kelly, Shiyao Li, K. Selva, Kathleen M. Wragg, K. Subbarao, Thi H. O. Nguyen, L. Rowntree, L. Allen, K. Bond, D. Williamson, N. Truong, M. Plebanski, K. Kedzierska, S. Mahanty, A. Chung, F. Caruso, A. Wheatley, J. Juno, S. Kent   +21 more
semanticscholar   +1 more source

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera

Science, 2022
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be ...
A. Muik, B. G. Lui, Ann-Kathrin Wallisch, Maren Bacher, Julia Mühl, J. Reinholz, O. Ozhelvaci, Nina Beckmann, Ramón de la Caridad Güimil Garcia, A. Poran, S. Shpyro, Andrew Finlayson, Hui Cai, Qi Yang, K. Swanson, Ö. Türeci, U. Şahin   +16 more
semanticscholar   +1 more source

Treponema pallidum mRNA-LNP vaccine candidate encoding TP0954 induces strongly protective immunity in rabbits

Frontiers in Immunology
IntroductionSyphilis is a sexually or vertically transmitted disease caused by the infection of Treponema pallidum (T. pallidum). Syphilis prevalence has risen globally despite the availability of effective treatments.
Zhiyu Lu, Yizhou Lu, Di Liu, Fangzhi Du, Qingyun Wu, Guoyang Liao, Yanan Wu, Rui-Li Zhang, Jian Zhou, Qianqiu Wang   +9 more
doaj   +1 more source

mRNA vaccine in cancer therapy: Current advance and future outlook

Clinical and Translational Medicine, 2023
Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer.
Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qi She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li   +10 more
semanticscholar   +1 more source

mRNA vaccines for cancer immunotherapy

Frontiers in Immunology, 2022
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA vaccines are an attractive and powerful immunotherapeutic platform against cancer because of their high potency, specificity, versatility, rapid and large-scale development capability, low-cost manufacturing potential, and safety.
Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan   +4 more
openaire   +3 more sources

Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Reproductive Biology and Endocrinology, 2021
Objective No information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.
Raoul Orvieto, Meirav Noach-Hirsh, Aliza Segev-Zahav, Jigal Haas, Ravit Nahum, Adva Aizer   +5 more
doaj   +1 more source

mRNA Innovates the Vaccine Field [PDF]

Vaccines, 2021
Development of new vaccine modalities is a critical need to address many of the shortcomings of traditional platforms such as the lack of sufficient efficacy against certain pathogens or cancer; difficulties with production; or, in some cases, safety issues [...]
openaire   +3 more sources

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies

Nature, 2021
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries.
D. Collier, A. De Marco, I. Ferreira, B. Meng, R. Datir, A. Walls, Steven A Kemp S, J. Bassi, D. Pinto, C. Fregni, S. Bianchi, M. A. Tortorici, John E. Bowen, K. Culap, S. Jaconi, E. Cameroni, G. Snell, M. Pizzuto, A. F. Pellanda, C. Garzoni, A. Riva, A. Elmer, N. Kingston, B. Graves, Laura E. McCoy, Kenneth G. C. Smith, J. Bradley, Nigel James Temperton, L. Lourdes Ceron-Gutierrez, G. Barcenas-Morales, William T. Harvey, H. Virgin, A. Lanzavecchia, L. Piccoli, R. Doffinger, M. Wills, D. Veesler, D. Corti, Ravindra K. Gupta   +38 more
semanticscholar   +1 more source