Results 61 to 70 of about 1,693,659 (204)

mRNA vaccines

Frontiers in Immunology, 2023
The success of the first licensed mRNA-based vaccines against COVID-19 has created a widespread interest on mRNA technology for vaccinology. As expected, the number of mRNA vaccines in preclinical and clinical development increased exponentially since 2020, including numerous improvements in mRNA formulation design, delivery methods and manufacturing ...
Matarazzo, Laura, Bettencourt, Paulo J. G.   +1 more
openaire   +1 more source

Neo-Antigen mRNA Vaccines [PDF]

Vaccines, 2020
The interest in therapeutic cancer vaccines has caught enormous attention in recent years due to several breakthroughs in cancer research, among which the finding that successful checkpoint blockade treatments reinvigorate neo-antigen-specific T cells and that successful adoptive cell therapies are directed towards neo-antigens. Neo-antigens are cancer-
Arthur Esprit, Wout de Mey, Rajendra Bahadur Shahi, Kris Thielemans, Lorenzo Franceschini, Karine Breckpot   +5 more
openaire   +4 more sources

The mRNA vaccine, a swift warhead against a moving infectious disease target

Expert Review of Vaccines
Introduction The rapid development of mRNA vaccines against SARS-CoV-2 has revolutionized vaccinology, offering hope for swift responses to emerging infectious diseases.
Sheema Mir, Mohammad Mir
doaj   +1 more source

Heterologous booster vaccination with CoronaVac following prime vaccination with mRNA vaccine

Clinical & Translational Immunology, 2022
Objective Despite the high vaccine efficacy of mRNA COVID‐19 vaccines, there are individuals who developed excessive reactogenic and/or allergic responses after the first mRNA dose and were considered ineligible for further mRNA doses.
Yun Shan Goh, Siew‐Wai Fong, Angeline Rouers, Zi Wei Chang, Matthew Zirui Tay, Jean‐Marc Chavatte, Nicole Ziyi Zhuo, Pei Xiang Hor, Chiew Yee Loh, Yuling Huang, Joel Xu En Wong, Yong Jie Tan, Daniel Rui Xiang Lim, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Raphael Tze Chuen Lee, Surinder Pada, Louisa Jin Sun, Desmond Luan Seng Ong, Jyoti Somani, Eng Sing Lee, NCID Study Group, COVID‐19 Study Group, Sebastian Maurer‐Stroh, Cheng‐I Wang, Yee‐Sin Leo, Raymond TP Lin, Ee Chee Ren, David C Lye, Barnaby Edward Young, Poh Lian Lim, Lisa FP Ng, Laurent Renia   +33 more
doaj   +1 more source

Biodistribution of mRNA COVID-19 vaccines in human breast milkResearch in context

EBioMedicine, 2023
Summary: Background: COVID-19 mRNA vaccines play a vital role in the fight against SARS-CoV-2 infection. However, lactating women have been largely excluded from most vaccine clinical trials.
Nazeeh Hanna, Claudia Manzano De Mejia, Ari Heffes-Doon, Xinhua Lin, Bishoy Botros, Ellen Gurzenda, Christie Clauss-Pascarelli, Amrita Nayak   +7 more
doaj   +1 more source

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy

Frontiers in Cellular and Infection Microbiology
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response.
Saber Imani, Xiaoyan Li, Keyi Chen, M. Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Saloomeh Khoushab, Xiaoping Li   +7 more
semanticscholar   +1 more source

mRNA vaccine trafficking and resulting protein expression after intramuscular administration

Molecular Therapy: Nucleic Acids, 2023
The mRNA vaccine route from injection site to critical immunologic tissues, as well as the localization of protein antigen following intramuscular (i.m.) administration, is crucial to generating an effective immune response.
Kimberly J. Hassett, Ivana Liric Rajlic, Kapil Bahl, Rebecca White, Kristen Cowens, Eric Jacquinet, K. Burke   +6 more
semanticscholar   +1 more source

An mRNA vaccine induces antimycobacterial immunity by activating DNA damage repair and autophagy

Molecular Therapy: Nucleic Acids
Effective vaccines are urgently needed for the control of tuberculosis (TB). Here, we report that an mRNA TB vaccine is highly effective and exhibits both prophylactic and therapeutic activity in the zebrafish model of TB.
Dan Chen, Weili Huang, Lifang Shen, Junli Zhang, Zhifen Pan, Chen Zhang, Yuting Tang, Ziwei Zhou, Jie Tao, Geyang Luo, Shifeng Zhang, Jing Zhou, Shuqin Xu, Meng Zhang, Yeyu Li, Yi Fang, Fanfan Zhao, Lei Huang, Hangwen Li, Hua Yang, Hong Lv, Wei Sha, Bo Yan, Jun Liu, Lu Zhang   +24 more
doaj   +1 more source

Circulating Spike protein detected in post-COVID-19 mRNA vaccine myocarditis

Circulation, 2023
Background: Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these ...
L. Yonker, Z. Swank, Y. Bartsch, M. Burns, A. Kane, B. Boribong, Jameson P. Davis, M. Loiselle, T. Novak, Y. Senussi, Chi-An Cheng, Eleanor Burgess, A. Edlow, J. Chou, A. Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, M. Arditi, B. Julg, A. Randolph, G. Alter, A. Fasano, David R. Walt   +22 more
semanticscholar   +1 more source

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1

Cell Host and Microbe
Summary COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent ...
Qian Wang, Yicheng Guo, Anthony D. Bowen, Ian A. Mellis, R. Valdez, C. Gherasim, Aubree Gordon, Lihong Liu, D. Ho   +8 more
semanticscholar   +1 more source