Results 71 to 80 of about 1,693,659 (204)

Effectiveness of a bivalent mRNA vaccine booster dose to prevent severe COVID-19 outcomes: a retrospective cohort study

Lancet. Infectious Diseases (Print), 2023
Background In late 2022, the SARS-CoV-2 omicron (B.1.1.529) BA.5 sublineage accounted for most of the sequenced viral genomes worldwide. Bivalent mRNA vaccines contain an ancestral SARS-CoV-2 strain component plus an updated component of the omicron BA.4
R. Arbel, Alon Peretz, R. Sergienko, M. Friger, Tanya Beckenstein, Hadar Duskin-Bitan, S. Yaron, A. Hammerman, N. Bilenko, D. Netzer   +9 more
semanticscholar   +1 more source

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2

npj Vaccines
The COVID-19 pandemic spurred mRNA vaccine innovation, but new SARS-CoV-2 variants highlight the need for vaccines with improved potency and durability.
Jason P. Laliberte, Yingyun Cai, Tara Kenny, Yi Zhang, Kuishu Ren, Kim Rosenthal, Daniel Flores, Richard Roque, Oliver Acton, Vanessa Cadevilla Peano, Noel Janney, Vinita Puri, Sarah Siddiqui, Angela Pack, Giune Padilla, Seme Diallo, Hibret Adissu, Rakesh Choudhary, Hawley Pruitt, Yi-Han Cheng, George Thom, Michael Newton, Cheyne Kurokawa, Johnathan Guest, Phillip Swanson, Yueh-Ming Loo, Joseph R. Francica, Wade Blair, Mark Esser   +28 more
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Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar

New England Journal of Medicine, 2022
Background Waning of vaccine protection against coronavirus disease 2019 (Covid-19) and the emergence of the omicron (or B.1.1.529) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to expedited efforts to scale up ...
L. Abu-Raddad, H. Chemaitelly, H. Ayoub, S. AlMukdad, H. Yassine, H. Al-Khatib, M. Smatti, P. Tang, M Zahid Hasan, P. Coyle, Z. Al-Kanaani, E. Al-Kuwari, A. Jeremijenko, A. Kaleeckal, A. Latif, R. M. Shaik, H. Abdul-Rahim, Gheyath K Nasrallah, M. G. Al-Kuwari, A. Butt, H. Al-Romaihi, M. H. Al-Thani, A. Al-Khal, R. Bertollini   +23 more
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The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

Frontiers in Immunology, 2022
Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved
Reese Jalal Ladak, Reese Jalal Ladak, Alexander J. He, Yu-Hsun Huang, Yu Ding   +4 more
doaj   +1 more source

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Cell, 2021
Summary Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose.
R. Payne, S. Longet, J. Austin, D. Skelly, W. Dejnirattisai, S. Adele, N. Meardon, S. Faustini, S. Al-Taei, S. Moore, T. Tipton, L. Hering, A. Angyal, Rebecca Brown, A. Nicols, N. Gillson, S. Dobson, Ali Amini, P. Supasa, A. Cross, Alice Bridges-Webb, L. S. Reyes, Aline Linder, Gurjinder Sandhar, Jonathan A. Kilby, J. Tyerman, T. Altmann, H. Hornsby, R. Whitham, Eloise Phillips, T. Malone, Alec C. Hargreaves, A. Shields, A. Saei, S. Foulkes, Lizzie Stafford, S. Johnson, D. Wootton, C. Conlon, K. Jeffery, P. Matthews, J. Frater, A. Deeks, A. Pollard, Anthony Brown, S. Rowland-Jones, J. Mongkolsapaya, E. Barnes, Susan Hopkins, V. Hall, C. Dold, C. J. Duncan, A. Richter, M. Carroll, G. Screaton, T. D. de Silva, L. Turtle, P. Klenerman, S. Dunachie, Hibatullah Emily Syed Hossain Delowar Ahmed Mohammad M. Azim Abuelgasim Adland Adlou Akther Alhussni Ali Ansari, Hibatullah Abuelgasim, E. Adland, Syed Adlou, H. D. Akther, Ahmed Alhussni, Mohammad Ali, M. Ansari, C. Arancibia-Cárcamo, Martin Bayley, Helen Brown, Jem Chalk, M. Chand, A. Chawla, Senthil Chinnakannan, Jospeh Cutteridge, C. D. de Lara, Lucy Denly, Ben Diffey, Stavros Dimitriadis, T. Drake, T. Donnison, Maeva DuPont, D. Eyre, A. Fairman, S. Gardiner, Javier Gilbert-Jarmillo, P. Goulder, C. Hackstein, S. Hambleton, M. Haniffa, J. Haworth, Jennifer C. Holmes, E. Horner, Anni Jämsén, S. Johnson, Chris Jones, Mwila Kasanyinga, Sinéad Kelly, R. Kirk, Michael L. Knight, A. Lawrie, L. Lee, Lauren Lett, K. Lillie, Nicholas Lim, Hema Mehta, A. Mentzer, D. O’Donnell, A. Ogbe, M. Pace, Brendan A. I. Payne, G. Platt, Sonia Poolan, N. Provine, N. Ramamurthy, Nicholas G Robinson, L. Romaniuk, P. Rongkard, Oliver Sampson, Beatrice Simmons, J. Spegarova, Emily Stephenson, K. Subramaniam, James E. D. Thaventhiran, Sarah R. Thomas, S. Travis, S. Tucker, H. Turton, Adam W Watson, Lisa Watson, Esme Weeks, Robert Wilson, S. Wood, Rosalind J Wright, Huiyuan Xiao, A. Zawia   +135 more
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Comparison of Vaccine Platforms for Machupo Virus

Vaccines
Background/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson, Hiromi Muramatsu, Sachchidanand Tiwari, Sowmya Sriram, Fernanda Caroline Coirada, Norbert Pardi, Paul Bates   +6 more
doaj   +1 more source

Single self-cleaving mRNA vaccine expressing multiple viral structural proteins elicits robust immune responses and protects nursing piglets against PDCoV infection

Journal of Virology
As an emerging swine enteric coronavirus, porcine deltacoronavirus (PDCoV) poses a severe threat to the global swine industry and has demonstrated potential for cross-species transmission.
Ruiming Yu, Yingjie Bai, Liping Zhang, Peng Zhou, Zhongwang Zhang, Jun Yang, Yanzhen Lu, Dongsheng Wang, Yousheng Peng, Dan Li, Jian He, Yonglu Wang, Quanwei Zhang, Ligang Yuan, Huichen Guo, Li Pan, Xinsheng Liu   +16 more
doaj   +1 more source

Rational development of multicomponent mRNA vaccine candidates against mpox

Emerging Microbes and Infections, 2023
The re-emerging mpox (formerly monkeypox) virus (MPXV), a member of Orthopoxvirus genus together with variola virus (VARV) and vaccinia virus (VACV), has led to public health emergency of international concern since July 2022. Inspired by the unprecedent
Rong-Rong Zhang, Zheng-Jian Wang, Yi-Long Zhu, W. Tang, Chao Zhou, Suoqun Zhao, Meiting Wu, Tao Ming, Yongqiang Deng, Qi Chen, Ning Jin, Qing Ye, Xiao Li, C. Qin   +13 more
semanticscholar   +1 more source

Development of an Influenza/COVID-19 Combination mRNA Vaccine Containing a Novel Multivalent Antigen Design That Enhances Immunogenicity of Influenza Virus B Hemagglutinins

Vaccines
Background/Objectives: Developing next-generation mRNA-based seasonal influenza vaccines remains challenging, primarily because of the relatively low immunogenicity of influenza B hemagglutinin (HA) antigens.
Elena Thornhill-Wadolowski, Dana L. Ruter, Feng Yan, Mayur Gajera, Evan Kurt, Labannya Samanta, Kimberlin Leigh, Jianbo Zhu, Zhijun Guo, Zihao Wang, Yuanqing Liu, Jaewoo Lee, Marcin Bugno   +12 more
doaj   +1 more source

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes

Science, 2022
Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It is difficult to create effective prepandemic vaccines because it is uncertain which influenza virus subtype will cause the next pandemic.
C. P. Arevalo, M. Bolton, Valerie Le Sage, Naiqing Ye, Colleen Furey, Hiromi Muramatsu, M. Alameh, N. Pardi, E. Drapeau, Kaela Parkhouse, Tyler A. Garretson, J. S. Morris, L. Moncla, Ying K. Tam, Steven H. Y. Fan, S. Lakdawala, D. Weissman, S. Hensley   +17 more
semanticscholar   +1 more source