Results 71 to 80 of about 192,514 (206)

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

An mRNA vaccine provides effective protection against Duck Tembusu Virus infection

npj Vaccines
As an emerging flavivirus, Duck Tembusu virus (DTMUV) causes severe neurological disorder and acute egg drop syndrome in poultry. Herein, we report the development of a highly effective mRNA vaccine against DTMUV using lipid nanoparticle (LNP) delivery ...
Shi Xu, Lijiao Zhang, Caiyi Fei, Guilai Liu, Mengwei Xu, Rui Liu, Jing Li, Aili Wang, Qing He, Ke Cai, Qingtao Liu, Tiyun Han   +11 more
doaj   +1 more source

Development of an Influenza/COVID-19 Combination mRNA Vaccine Containing a Novel Multivalent Antigen Design That Enhances Immunogenicity of Influenza Virus B Hemagglutinins

Vaccines
Background/Objectives: Developing next-generation mRNA-based seasonal influenza vaccines remains challenging, primarily because of the relatively low immunogenicity of influenza B hemagglutinin (HA) antigens.
Elena Thornhill-Wadolowski, Dana L. Ruter, Feng Yan, Mayur Gajera, Evan Kurt, Labannya Samanta, Kimberlin Leigh, Jianbo Zhu, Zhijun Guo, Zihao Wang, Yuanqing Liu, Jaewoo Lee, Marcin Bugno   +12 more
doaj   +1 more source

ヒラメの獲得免疫制御に及ぼすサイトカインの影響 [PDF]

, 2015
東京海洋大学博士学位論文 平成25年度(2013) 応用生命科学 課程博士 甲第304号指導教員: 近藤秀裕全文公表年月日: 2018-05 ...
Taechavasonyoo Apichaya
core   +1 more source

PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge

mBio
Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes severe diarrhea in neonatal piglets, which is associated with a high mortality rate.
Yongxiang Zhao, Baochao Fan, Xu Song, Jie Gao, Rongli Guo, Cheng Yi, Zhaoming He, Hongpeng Hu, Jianhao Jiang, Lixiang Zhao, Tianyi Zhong, Bin Li   +11 more
doaj   +1 more source

Varicella zoster virus mRNA vaccine candidate induced superior cellular immunity and comparable humoral and Fc-mediated immunity compared to the licensed subunit vaccine in a mouse model

Human Vaccines & Immunotherapeutics
The threat of herpes zoster (HZ) is increasing, particularly in the elderly and immunocompromised individuals. Although two platform vaccines are currently available for HZ prevention, the low effectiveness of the live attenuated varicella-zoster virus ...
Eun-Jeong Jang, Sivilay Xayaheuang, Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Seok-Tae Choi, Hye Won Kwak, Jae-Hwan Nam, Keunea Kim, Boomi Yoon, Jae Hyang Lim, Ho Seong Seo, Chang-Hoon Woo, Hosun Park   +13 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice [PDF]

, 2016
Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture ...
Aislynn Taggart, Anna Janowicz, BMJ Group, Frauke Seehusen, Ilaria M. Piras, Kerstin Hahn, Marco Caporale, Mariana Varela, Massimo Palmarini, Rute Maria Pinto, S. López, William Marciel de Souza, Wolfgang Baumgärtner, Xiaohong Shi   +13 more
core   +1 more source

In Gratitude for mRNA Vaccines

New England Journal of Medicine, 2021
mRNA Vaccine Research and the Lasker–DeBakey Award Although the production time (11 months) of the messenger RNA vaccines against SARS-CoV-2 infection set a record, the preclinical research undergi...
openaire   +2 more sources

An Mpox Multi-Antigen-Tandem Bivalent mRNA Candidate Vaccine Effectively Protects Mice Against the Vaccinia Virus

Vaccines
Background: Since the outbreak of mpox in 2022, the disease has spread rapidly worldwide and garnered significant public attention. Vaccination is regarded as an effective measure to prevent the spread of mpox.
Jun Zuo, Jiayu Wu, Zhen Zhang, Jinrong Long, Changxiao Yu, Yuqin Liao, Hongsheng Zhang, Jing Yang   +7 more
doaj   +1 more source