Results 91 to 100 of about 192,514 (206)

PASD1: a promising target for the immunotherapy of haematological malignancies [PDF]

, 2013
In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in ...
Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Mills, Ken I., Pulford, Karen   +4 more
core   +3 more sources

Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus

Cell Reports
Summary: The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is a need to develop more effective and safer mpox virus (MPXV)-specific vaccines in response to the ...
Tianxi Ye, Jinge Zhou, Chen Guo, Kaiyue Zhang, Yuping Wang, Yanhui Liu, Junhui Zhou, Yalin Xie, Entao Li, Rui Gong, Jiancun Zhang, Xia Chuai, Sandra Chiu   +12 more
doaj   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
A. S. McKee, Alving, Atochina, Beutler, Bomford, Brewer, Brewer, Brogdon, Cambier, Crawford, Cunningham, F. Crawford, Gavin, Grun, Grzych, Hoebe, J. W. Kappler, J. White, Jordan, Kaisho, Kane, Kapsenberg, Kawai, Lang, Layland, Li, Liu, M. MacLeod, MacDonald, McDonald, Medzhitov, Mohrs, Morefield, Noben-Trauth, Okano, Ouyang, P. Marrack, Pearce, Pollock, Reese, Schnare, Sokolovska, Steinman, Sun, Trinchieri, Whelan   +45 more
core   +1 more source

Feeding driet chicory root to pigs decrease androstenone accumulation in fat by increasing hepatic 3β hydroxysteroid dehydrogenase expression [PDF]

, 2012
The present study investigated the in vivo effect of chicory root on testicular steroid concentrations and androstenone metabolizing enzymes in entire male pigs.
Brunius, Carl, Ekstrand, Bo, Rasmussen, Martin Krøyer, Zamaratskaia, Galia   +3 more
core  

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

Frontiers in Immunology
Ebola virus (EBOV) is the causative agent of Ebola disease (EBOD), a viral hemorrhagic fever with a notably high case fatality rate. Current treatments for EBOD are limited to monoclonal antibodies or two licensed viral vector vaccines, a recombinant ...
Zachary R. Stromberg, Elvia E. Silva, Sara C. Johnston, Dylan M. Johnson, Dominique Hall, Emmanuel F. Adjei, Emmanuel F. Adjei, John A. Altin, Abisola Abisoye-Ogunniyan, Travis Gollott, Wei He, Iris K. A. Jones, Steve Kwilas, Sean J. Lund, Heather L. Mead, Georgia A. Nelson, Lisa Ouyang, Sandra K. G. Peters, Jennifer L. Schwedler, Caleb Z. Trecazzi, Matthew W. Turner, Chunyan Ye, Steven B. Bradfute, Nicholas O. Fischer, Jay W. Hooper, Jason T. Ladner, Jason T. Ladner, Amy Rasley, Amy Rasley, Oscar A. Negrete   +29 more
doaj   +1 more source

A review of coronavirus infection in the central nervous system of cats and mice. [PDF]

, 2001
Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the ...
Foley, JE, Leutenegger, C
core  

A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen

Vaccines
Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV.
Mengyuan Liu, Yixuan Liu, Shaohui Song, Qiurong Qiao, Jing Liu, Yun Xie, Jian Zhou, Guoyang Liao   +7 more
doaj   +1 more source

Reactivity of human and porcine natural interferon-alpha producing cells to immunostimulatory DNA [PDF]

, 2003
The interferon-α (IFN-α) inducing capacity of various forms of immunostimulatory DNA and the identity of the IFN-α producing cells (IPC) were studied in human and porcine leukocytes.
Magnusson, Mattias
core